Yersin was born in 1863 in Aubonne, Canton of Vaud, Switzerland, in a family originally from France. From 1883 to 1884, Yersin studied medicine at Lausanne, Switzerland; and then at Marburg, Germany and Paris (1884-1886). In 1886, he entered Louis Pasteur's research laboratory at the École Normale Supérieure, by invitation of Emile Roux, and participated in the development in the anti-rabies serum. In 1888 he received his doctoral dissertation with a thesis on Étude sur le Développement du Tubercule Expérimental and spent two months with Robert Koch in Germany. He joined the recently created Pasteur Institute in 1889 as Roux's collaborator, and discovered with him the diphtheric toxin (produced by the Corynebacterium diphtheriae bacillus).
In order to practice medicine in France, Yersin applied to and obtained French nationality in 1888. Soon afterwards (1890), he left for French Indochina in Southeast Asia as a physician to the Messageries Maritimes company, in the Saigon-Manila line and then in the Saigon-Haiphong line. In 1894 Yersin was sent by request of the French government and the Pasteur Institute to Hong-Kong, to investigate the ongoing Manchurian Pneumonic Plague epidemic, and there, in a small hut next to the institute ( from "Plague" by Wendy Orent) along with his co-discoverer Shibasaburo Kitasato, he made his greatest discovery, that of the pathogen which causes the disease. He was also able to demonstrate for the first time that the same bacillus was present in the rodent as well as in the human disease, thus underlining the possible mean of transmission. This important discovery was communicated to the French Academy of Sciences in the same year, by his colleague Emile Duclaux, in a classic paper titled La Peste Bubonique A Hong-Kong (Ann. Inst. Pasteur. 8 662-667).
From 1895 to 1897, Yersin further pursued his studies on the bubonic plague. In 1895 he returned to the Institute Pasteur in Paris and with Émile Roux, Albert Calmette and Amédée Borrel, prepared the first anti-pest serum. In the same year, he returned to Indochina, where he installed a small laboratory at Nha Trang, in order to manufacture the serum (in 1905 this laboratory was to become a branch of the Pasteur Institute). Yersin tried the serum received from Paris in Canton and Amoy, in 1896, and in Bombay, India, in 1897, with disappointing results. Having decided to stay in his country of adoption, he participated actively in the creation of the Medical School of Hanoi in 1902, and was its first director, until 1904.
