Thyroid-stimulating hormone (also known as
TSH or
thyrotropin) is a
peptide hormone synthesized and secreted by
thyrotrope cells in the
anterior pituitary gland which regulates the endocrine function of the
thyroid gland.
[1]TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3).[2] TSH production is controlled by thyrotropin-releasing hormone (TRH), which is manufactured in the hypothalamus and transported to the anterior pituitary gland via the superior hypophyseal artery, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus, and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release.
The level of thyroid hormones (T3 and T4) in the blood have an effect on the pituitary release of TSH; when the levels of T3 and T4 are low, the production of TSH is increased, and conversely, when levels of T3 and T4 are high, then TSH production is decreased. This effect creates a regulatory negative feedback loop.
TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit.
