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Search Results - Thyroxine

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Thyroxine, or 3,5,3',5'-tetra­iodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland. Thyroxine is synthesized via the iodination and covalent bonding of the phenyl portions of tyrosine residues found in an initial peptide, thyroglobulin, which is secreted into thyroid granules. These iodinated diphenyl compounds are cleaved from their peptide backbone upon being stimulated by thyroid stimulating hormone. More in the T3 and T4 section of thyroid.

T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development. Administration of thyroxine has been shown to significantly increase the concentration of nerve growth factor in the brains of adult mice.[1]

Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3) which is about four times more potent. T4 is converted in the tissues by deiodinases, including thyroid hormone iodine peroxidase (TPO), to T3. The "D" isomer is called "Dextrothyroxine"[2] and is used as a lipid modifying agent.[3] The half-life of thyroxine once released into the blood circulatory system is about 1 week.

The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.

Showing 1 to 24 of 24 Articles matching 'Thyroxine' in related articles.
Pages: 1

1. Thyroid and Metabolism
October 27, 2009

Thyroid-The Bodies Metabolic Thermostat. Whenever someone says I have a sluggish metabolism I always think of the thyroid gland. The thyroid gland is located in the neck and is one of the bodies largest endocrine glands. The thyroid gland has many functions within the body including controlling how fast the body metabolizes food, makes proteins, and controls the body's sensitivity to other hormones. The thyroid is controlled by the hypothalamus and the pituitary gland. The primary function of the thyroid however is to produce thyroxine, triiodothyronine a... (read more)

Author: Larry Vestal

2. Anatomy of the Thyroid Gland and Functions in the Endocrine System
October 08, 2009

The thyroid gland is situated on the front part of the neck. Upon palpation, the thyroid gland will feel rubbery to the hands of the examiner. The thyroid gland is made up of follicular and parafollicular cells which secrete various hormones needed by the body to maintain normal function. The Functions of the Thyroid Gland in the Endocrine System • T3 and T4 Function T4, also known as Thyroxine, is responsible for the regulation of oxygen consumption of the cells in the body. T4 is necessary to maintain normal metabolic rate in the body. T3 or Triiodothyronine, offers the s... (read more)

Author: Adam Rise

3. How Levothroid can help you overcome thyroid deficiency
September 18, 2009

The thyroid gland is a small, butterfly - shaped endocrine gland found in the front base of the neck. It is one of the largest endocrine glands in the body and produces two thyroid hormones - Thyroxine (T4) and Triiodothyronine (T3), which mainly regulate the body’s metabolic rate as well as regulate the growth and functioning of other body systems. This gland also produces calcitonin, a hormone that plays an important role in a process called calcium homeostasis (a process by which the body maintains calcium levels). The thyroid gland may be affected by two common disorders, viz.,... (read more)

Author: noble drugstore

4. Hyperthyroidism
August 20, 2009

Hypothyroidism occurs what time the thyroid gland, located next to the front of the collar merely under the Adam's apple, reduces production of the hormone thyroxine. Thyroxine is mature in support of balancing the physically processes and metabolism. A drop level of thyroxine (also spelled thyroxin) process the body's metabolism is cheap before lowered. According to Encarta Dictionaries, the word "metabolism" has two meanings: 1. Life-sustaining element action: The chain of processes by which food is converted into the energy and products wanted to sustain life. 2. Element action con... (read more)

Author: Awad Abdelkarim

5. When do we men stop growing
August 10, 2009

To assess growth and development during puberty it is important to evaluate sexual a persons maturity ratings and also physiologic changes. These correlate to normal growth levels. Many of the body's hormones influence growth, such as the growth hormones insulin and thyroxine, The rate at which the human bone matures is affected by the thyroid hormones, and gonadal sex steroids, mainly estrogen. Heightened levels of estrogen secretion can lead to advanced rate of growth, making some kids taller than there friends and double there friends size in extreme cases close double there s... (read more)

Author: Ciaran Leeper

6. Thyroid-Hormone-Suppressive Therapy With Levothyroxine
August 03, 2009

Levothyroxine or L-thyroxine is a synthetic form of the thyroid hormone thyroxine. In its natural form, thyroxine is also in its L-form. This synthetic hormone is used as a supplement for hypothyroid patients who are incapable of producing sufficient quantities of thyroid hormone to maintain normal physiologic functions. Indications and Contraindications Around forty percent of doctors recommend this synthetic hormone for the treatment of solitary thyroid nodules but there are some instances when its administration is deemed inappropriate. One of the factors to be considered in prescribin... (read more)

Author: Ryan English

7. Fate of Iodine in Thyroid Hormone Formation - Why Iodine is Necessary For Thyroid Hormone Formation
August 03, 2009

To form sufficient quantities of the thyroid hormone thyroxine or T4, about 50 milligrams of iodine in the form of iodides in the diet is required every year. This just shows how important iodine is in the process of thyroid hormone formation and consequently, the regulation of the body’s metabolism. Iodides in the Diet The iodides available in your food are absorbed in the gastrointestinal in much the same way as chlorides. These are then normally rid of by the kidneys through the urine but not before the thyroid gland gets its share of iodides. This share constitutes about a fifth of t... (read more)

Author: Ryan English

8. Antithyroid Substances - The Three Best Known Antithyroid Drugs
August 03, 2009

Drugs that are known to inhibit the secretion of thyroid hormones are generally known as antithyroid substances. Three of the best known antithyroid substances are propylthiouracil, thiocyanate, and inorganic iodides. Each of this drugs blocks thyroid secretion in a different way and the different mechanisms by which they do so are further explained. Propylthiouracil Propylthiouracil — and its relatives, methimazole and carbimazole — decrease thyroid hormone formation by preventing its formation from iodides and tyrosine. This drug acts by blocking the peroxidase enzyme that is neces... (read more)

Author: Ryan English

9. Subclinical Hypothyroidism and Its Adverse Pregnancy Outcomes
August 03, 2009

Subclinical Hypothyroidism Subclinical hypothyroidism, also known as mild hypothyroidism, is usually asymptomatic or if it does manifest itself, it may present with vague symptoms that could be attributed to other causes. Patients with subclinical hypothyroidism have elevated serum levels of the thyroid-stimulating hormone while maintaining normal levels of thyroxine and triiodothyronine and may occur in the presence or absence of thyroid antibodies. A common cause for subclinical hypothyroidism in areas with sufficient iodine sources is Hashimoto’s disease. In Hashimoto’s disease, a... (read more)

Author: Ryan English

10. How Can Thyroid Affect Menopause?
August 03, 2009

What is Thyroid Gland? There are various glands found in a human body. These glands help the body to function properly. One of the most important and the largest of such glands is thyroid gland. The function of thyroid gland is to regulate the metabolism of the human body. This gland secretes two hormones, thyroxine and triiodothyronine. The hormones which are secreted also include calcium homeostasis and calcitonine. What if it stops functioning properly? When the thyroid gland ceases to function properly, it normally results in two types of disorders, hypothyroidism and hypert... (read more)

Author: Ryan English

11. Thyroid health
July 07, 2009

Some of the vital body functions we tend to take for granted are growth, development, metabolism, organ function, fertility, etc. The regulation of these vital tasks is due to one tiny endocrine gland – the thyroid - located in your neck just below your Adam's apple. The thyroid is responsible for producing two hormones and carefully regulating them. They are tri-iodothyronine (T3) and thyroxine (T4). The thyroid uses Iodine, which can be found in seafood and salt, to make these two hormones. These hormones are extremely important as every cell in the body depends upon thyroid hormones fo... (read more)

Author: Sam Smith

12. Hyperthyroidism in cats
July 06, 2009

Hyperthyroidism is one of the most common disorders of the endocrine (hormone) gland that affects a huge population of cats. It can severely affect pet health and needs to be taken care of before it causes severe pet health problems. The thyroid gland is situated in neck of your cat and is quite small in size. It produces a thyroid hormone also known as thyroxine (T4) as well as small amounts of triiodothyronine (T3). These hormones help in regulating the metabolic rate of the cat’s body and can affect the working of every system or organ in his body. The thyroid stimulating hormone (TSH)... (read more)

Author: Mark Stimpson

13. Living With Hypothyroidism The Natural Way
December 31, 2008

In todays fast food society and poor eating habits, have given way to serious health problems. One of these is hypothyroidism. Hypothyroidism is an ailment where the thyroid gland doesn't produce the required thyroxine hormone useful in balancing the body's metabolic functions. The human body is made up of many crucial elements; all of them performing a key part in the nurturing of human life and enabling the optimal functioning of the body system. Part of these important components are the different hormones. One of which is thyroxine. When the body lacks of these important hormones, the... (read more)

Author: Lamar Deane

14. What is Hypothyroidism?
October 30, 2008

Hypothyroidism is a condition in which the thyroid gland fails to produce sufficient amounts of thyroid hormones (thyroxine (T4) and triiodothyronine (T3)). Hypothyroidism is associated with a decreased metabolic rate. Over 5 million Americans suffer from this condition, and many of them don't even realize it. The thyroid gland can be found just below the larynx, in front of and to either side of the trachea (windpipe). Historically, iodine deficiency was the main cause for hypothyroidism. The thyroid gland is the only tissue in our body that can absorb iodine and iodine is essential for ... (read more)

Author: Bart Nieuwenhuijsen

15. Is Your Thyroid Making You Gain Weight?
October 07, 2008

The thyroid, sometimes called our "master gland," is a small gland, shaped like a butterfly, located in the lower part of your neck. The thyroid gland is responsible for producing the hormones, triiodothyronine (T3) and thyroxine (T4), which control metabolism. These thyroid hormones regulate energy levels, body temperature, and weight. So, is your thyroid making you gain weight? Read on. If there are any disruptions or disease afflicting this area, it may cause you to have difficulties with metabolism leading to weight fluctuations - you may either gain weight, lose weight, or may find that l... (read more)

Author: ROBIN REICHERT

16. Hyperthyroidism - Causes, Symptoms And Treatment
April 04, 2008

Hyperthyroidism is a condition in which the thyroid gland becomes overactive and secretes excessive amounts of the hormone thyroxine. The thyroid is a small, somewhat butterfly-shaped structure located at the base of the neck. The hormone it produces, thyroxine, is converted in the liver into another hormone, tri-iodothuronine, which regulates metabolism. If the thyroid produces too much thyroxine, this ultimately throws the baby's metabolic processes into overdrive and speeds up many of the functions of the body. The thyroid gland is located in the front of the neck, just below the laryn... (read more)

Author: Peter Hutch

17. Hyperthyroidism - Causes, Symptoms And Treatment
March 31, 2008

Hyperthyroidism is a condition in which the thyroid gland becomes overactive and secretes excessive amounts of the hormone thyroxine. The thyroid is a small, somewhat butterfly-shaped structure located at the base of the neck. The hormone it produces, thyroxine, is converted in the liver into another hormone, tri-iodothuronine, which regulates metabolism. If the thyroid produces too much thyroxine, this ultimately throws the baby's metabolic processes into overdrive and speeds up many of the functions of the body. The thyroid gland is located in the front of the neck, just below the laryn... (read more)

Author: Peter Hutch

18. Therapy For Graves Disease
March 28, 2008

Graves disease is an autoimmune disorder that involves overactivity of the thyroid gland (hyperthyroidism). It occurs when your immune system mistakenly attacks your thyroid gland and causes it to overproduce the hormone thyroxine. he other causes of thyroid hormone excess are described in other sections of this book. Excess thyroid hormone causes a widespread disturbance in metabolism, since thyroid hormone effectively regulates the metabolic level in the body. Several factors can influence a person's susceptibility to Graves' disease. Hormone levels are probably important in the initiation o... (read more)

Author: Juliet Cohen

19. Discover Hypothyroidism In Beagles
February 21, 2008

Though they are not at greater risk of hypothyroidism, Beagles in rare cases have the tendency to develop this disease. Notice your Beagle shedding hair? Check it out because it may not be a skin infection caused by fleas and ticks, the shedding maybe because of hypothyroidism. The thyroid gland is one of the largest endocrine glands in the body. It is consist of two lobes located at the base of the neck. This gland is known for it produces thyroxine, a hormone that regulates the body's metabolic rate. This hormone controls how quickly the body burns calories and makes proteins. When thyr... (read more)

Author: Richard Cussons

20. Ephedrine
December 19, 2007

Ephedrine is a sympathomimetic drug and not a hormone compound. It offers athletes three distinct advantages in spite of not being a hormone compound. Ephedrine has clear fat burning characteristics. This occurs since Ephedrine produces heat in the body (thermogenesis). Simplified, Ephedrine slightly increases the body temperature so that the body burns more calories than usual. Ephedrine also stimulates the thyroid gland to transform the weaker LT-4 (L-thyroxine) into the stronger LT-3 (liothyronine), thus accelerating the metabolism. This fat burning effect, with the additional intake o... (read more)

Author: mark henry

21. Hypothyroidism - Causes, Symptoms and Treatment Methods
September 14, 2007

Hypothyroidism is a condition in which the body lacks sufficient thyroid hormone. Hypothyroidism is also known as an underactive thyroid. It occurs when the thyroid gland does not make enough thyroxine. Many of the symptoms of hypothyroidism are very subtle and are experienced by people without thyroid disease. Thus, a lot of physicians overlook the symptoms of fatigue, weight gain and depression and attribute them to other causes. It is a relatively common disease in purebred domestic dogs as well, and can have a hereditary basis in dogs. The risk of developing hypothyroidism tends to increas... (read more)

Author: Juliet Cohen

22. Graves' Disease - Causes, Symptoms and Treatment Methods
September 03, 2007

Graves' disease is the only kind of hyperthyroidism that has inflammation of the eyes, swelling of the tissues around the eyes, and bulging of the eyes. Graves-Basedow disease, also known simply as Graves' disease. Graves' disease is the most common form of hyperthyroidism. It occurs when your immune system mistakenly attacks your thyroid gland and causes it to overproduce the hormone called thyroxine. When the thyroid is too active, it makes more thyroid hormones than the body needs. High levels of thyroid hormones can cause side effects such as weight loss, rapid heart rate and nervousness. ... (read more)

Author: Juliet Cohen

23. Answers about thyroid disorders
May 09, 2007

Many people care to know as many information as possible related to what they are interested. Medical problems lead to a desperate need of information for the patients and their close ones. Thyroid problems are able to change your life permanently and that is why we felt like answering to some general questions about thyroid problems might help the ones in need. First of all people want to know if it is treatable. It is good to know that thyroid problems are generally easy to treat. Before answering to this question it is good to know that thyroid produces two primary hormones thyroxine... (read more)

Author: Fabiola Groshan

24. Grave's Disease and Hyperthyroidism
February 10, 2006

One of the main causes of hyperthyroidism is Graves' Disease. Graves' Disease, an autoimmune disease that sees an individual's thyroid gland as a foreign object invading the body and produces antibodies to attack the gland. This causes the thyroid gland to produce a greater than normal amount of thyroxine. As a person's thyroxine level increases, the body's metabolic rate increases as well. A higher metabolism rate can lead to a number of health problems, including irregular heartbeat and anxiety disorders. Graves' Disease occurs mostly in middle-aged women, but it has also been known... (read more)

Author: Amanda Baker

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