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The paper shows that damaged muscle tissues can be treated withcells derived from the fluids which surround the fetus duringdevelopment, leading to satisfactory regeneration and muscleactivity. The treatment resulted in longer survival in miceaffected by a muscle variant of spinal muscular atrophy. This isthe first time that regeneration of diseased muscle tissue has beenobtained using cells derived from amniotic fluid. The research appears in the journal Stem Cells , is authored by Dr Paolo de Coppi (UCL Institute of Child Healthand surgeon at Great Ormond Street Hospital) and colleagues inParis and Padova, and represents an impressive development in thegrowing field of regenerative medicine. Muscle derived stem cells are presently considered the best sourcefor muscle regeneration. However they cannot be used to treatmuscular dystrophies because the stem cells themselves are affectedin individuals with these conditions. Due to this challenge, othercell sources have been explored but so far no definitive treatmenthas been successful. De Coppi's team has demonstrated that intravenous transplantationof amniotic fluid stem (AFS) cells enhances the muscle strength andimproves the survival rate of the affected animals. This is thefirst study to demonstrate the functional and stable integration ofAFS cells into skeletal muscle, highlighting their value as a cellsource for the treatment of muscular dystrophies. However, the research is still at a relatively early stage as thework has only been carried out in animal models. Dr Coppi said: "Spinal muscular atrophy is a genetic diseaseaffecting one in 6,000 births. It is currently incurable and in itsmost severe form children with the condition may not survive longinto childhood. Children with a less severe form face the prospectof progressive muscle wasting, loss of mobility and motor function.There is an urgent need for improved treatments. "We are excited by this potential new approach forregenerating skeletal muscle tissue, but much more research isneeded. We now need to perform more in-depth studies with human AFScells in mouse models to see if it is viable to use cells derivedfrom the amniotic fluid to treat diseases affecting skeletal muscletissue." The study, published in Stem Cells , was funded by Great Ormond Street Hospital Children's Charity;Hopital Neker, Paris; and Cariparo and Città della Speranzain Italy. I am an expert from perfumescentedcandles.com, while we provides the quality product, such as China Outdoor Citronella Candles , Handmade Scented Candles Manufacturer, Christmas Scented Candles,and more.
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