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Computational modeling increases our knowledge of lipoproteinproperties that cannot be measured using experimental methods.Lipoproteins are particles that transport cholesterol in our bloodstream. According to the doctoral dissertation ofMaster of Science in Technology Linda Kumpula (Aalto UniversitySchool of Science), the differences in the composition, size andnumber of lipoprotein particles transporting cholesterol inindividuals can be computationally modeled using experimental data.The lipids transported by the particles have been establishedearlier, but it has not been possible to determine their content inone particle. Modeling can be used to calculate the size of one lipoproteinparticle when the number and volume of the lipids and proteins areknown. The cholesterol-transporting particles of differentindividuals are slightly different in size. The size differencedepends on issues such as how many cholesterol molecules there arein one lipoprotein particle. The risk of getting a cardiovasculardisease varies depending on the size, number and possibly also thelipid composition of, for instance, LDL particles - lipoproteinscontaining so-called bad cholesterol. If there is a significantnumber of LDL particles and they are small, the risk ofcardiovascular disease may be greater since the small particles canenter the arterial walls more easily than larger ones. A lot of research has been carried out on the structure andproperties of lipoproteins, but the details of their structure arestill fairly unknown. Computational modeling can be used to examinewhether lipids are located in the core or on the surface oflipoprotein particles. This study has disproved earlier hypotheseson the location of lipid molecules. The lipids that are morecommonly found in the core can also be located on the surface of aparticle. "This study shows that there are differences between individualswhen it comes to the particles that transport cholesterol. In thefuture, the significance of these differences from the point ofview of preventing cardiovascular diseases would be an interestingarea to explore," Linda Kumpula comments on her dissertation. An important aspect of this study is its usefulness when applyingnew, experimental methods, such as NMR spectroscopy for example, tothe study of lipoproteins and possible clinical use in the future.Another interesting fact is that the method used in Linda Kumpula'sdoctoral dissertation, developed by a group at Aalto University,has only been developed by one other group in the United States. Sources: Aalto University, AlphaGalileo Foundation . Additional References Citations. I am an expert from uninterrupted-power-supply.com, while we provides the quality product, such as Industrial Grade UPS Manufacturer , 0.9 Output Power Factor UPS, High Frequency Online UPS,and more.
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