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Meta-analysis suggests preventing diabetes can lower incidence ofleukemia, lymphoma, myeloma by icdenta icdenta





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Meta-analysis suggests preventing diabetes can lower incidence ofleukemia, lymphoma, myeloma by
Article Posted: 10/02/2013
Article Views: 159
Articles Written: 1096
Word Count: 467
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Meta-analysis suggests preventing diabetes can lower incidence ofleukemia, lymphoma, myeloma


 
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Patients with type 2 diabetes have a 20 percent increased risk of developing blood cancers , such as non-Hodgkin lymphoma , leukemia and myeloma , according to a new meta-analysis led by researchers at The MiriamHospital. The findings, published online in the journal Blood , the journal of the American Society of Hematology, add to thegrowing evidence base linking diabetes and certain types of cancer. "I think when most people think about diabetes-related illnesses,they think of heart disease or kidney failure, but not necessarily cancer," said lead authorJorge Castillo, M.D., a hematologist/oncologist with The MiriamHospital. "But when you consider that more than 19 millionAmericans have been diagnosed with diabetes not to mention themillions more who are either undiagnosed or will be diagnosed inthe future a 20 percent increased risk of blood cancer is quitesignificant." While diabetes has been previously associated with other types ofcancer, such as liver and pancreatic cancer , there have been few connections to blood cancers. Researchers arestill unclear what causes the vast majority of these malignancies,which include cancers of the blood, bone marrow, and lymph nodesand affect more than 100,000 Americans each year.

Castillo and colleagues analyzed 26 previously published researcharticles on the association between type 2 diabetes - the mostcommon form of the disease - and the incidence of lymphoma,leukemia and myeloma. The meta-analysis included more than 17,000cases of type 2 diabetes and blood cancer worldwide. They concluded patients with type 2 diabetes have increased odds ofdeveloping leukemia, myeloma and non-Hodgkin lymphoma, as well as asubtype of non-Hodgkin lymphoma known as peripheral T-celllymphoma. They did not find any associations with Hodgkin lymphoma. Interestingly, researchers also say the odds of lymphoma, leukemiaand myeloma appear to differ depending on the geographic region ofthe original report.

For example, the odds of non-Hodgkin lymphomawere higher in Asia and Europe, while there was an increasedleukemia risk in the United States and Asia. Although the study did not identify a cause for any of theseassociations, the findings suggest type 2 diabetes could beassociated with approximately five percent of all incidents ofleukemia, myeloma non-Hodgkin lymphoma. "It's important to remember that type 2 diabetes can, to somedegree, be prevented and controlled through lifestyle modification,such as diet and exercise," Castillo said. "So by preventing theonset of type 2 diabetes, we could also prevent blood cancer." The researchers say additional studies are needed to explain thepotential relationship between type 2 diabetes and blood cancers.In particular, Castillo believes future research should focus onthe role of behavioral factors like obesity , physical activity and smoking, which have been linked to bothdiabetes and cancer. Additional References Citations.

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