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High levels of "good" (high density lipoprotein) HDL cholesterol seem to cut the risk of bowel cancer , suggests research published online in Gut . The association is independent of other potentially cancer-inducingmarkers of inflammation in the blood. The researchers base their findings on participants in the EuropeanProspective Investigation into Cancer and Nutrition (EPIC) study.This is tracking the long term impact of diet on the development of cancer in more than half a million people in 10 European countries,including the UK. Some 1,200 people who developed bowel and rectal cancers - 779bowel and 459 rectal cancer - after agreeing to take part in EPICwere matched with another 1,200 participants of the same age,gender, and nationality. Blood samples taken when they joined the study, and the dietaryquestionnaires these participants had completed, were compared tosee if there were any discernible differences between the twogroups. The analysis showed that those who had the highest levels of HDLcholesterol, and another blood fat, apolipoprotein A, or apoA - acomponent of HDL cholesterol - had the lowest risk of developingbowel cancer. Each rise of 16.6 mg/dl in HDL and of 32 mg/dl in apoA reduced therisk of bowel cancer by 22% and 18%, respectively, after takingaccount of diet, lifestyle, and weight. But HDL and apoA levels had no impact on the risk of rectal cancer. After excluding those who had only been monitored for two years, asthey may have already been undergoing cancerous changes when theyjoined the study, only levels of HDL were associated with areduction in bowel cancer risk. The association remained intact, irrespective of other indicatorsof inflammation, insulin resistance, and oxygen free radicalslevels, all of which are associated with the development of cancer. The authors explain that low HDL levels have been linked to higherlevels of proteins involved in inflammation, while higher levels ofproteins that dampen down the inflammatory response have also beenlinked to high HDL levels. The pro inflammatory proteins boost cell growth and proliferationwhile curbing cell death, so HDL may alter the inflammatory processin some way, they suggest. Link to Article Source Gut (British Medical Journal) Additional References Citations. The e-commerce company in China offers quality products such as China Gantry Machining Center , Vertical Machining Center, and more. For more , please visit Vertical Machining Center today!
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