According to a study in the February edition of Liver Transplantation , a journal published by Wiley-Blackwell on behalf of the AmericanAssociation for the Study of Liver Diseases, preoperativecardiopulmonary exercise testing (CPET) is a specific predictor of90-day survival after liver transplantation. The findings revealthat the CPET measurement, the anaerobic threshold or fitnesslevel, is an important predictor of mortality in patients followingtransplantation. CPET is a non-invasive approach of measuring patients'cardiorespiratory fitness and has already been utilized to predictmorbidity and mortality after other major surgeries. Dr. James Prentis from Freeman Hospital in Newcastle upon Tyne inthe U.K. explains: "Liver transplantation carries a significant mortality risk in theearly days following surgery. An accurate preoperative assessmentlike CPET could help minimize patient mortality and optimizelimited donor organs." In the new study, researchers included CPET over three years aspart of the preoperative evaluation in 182 patients who underwentliver transplantation at Freeman Hospital. CPET was defined as theability to determine the anaerobic threshold. Of all patients, 165(91%) successfully completed the CPET, with follow-up after thetransplantation to determine 90-day mortality, critical care andduration of hospital stay. The findings revealed that from 60 patients (33%) who received aliver transplant, 6 patients (10%) died after the transplantation.The researchers established that the average anaerobic thresholdwas substantially higher in those who survived compared with thosewho died, and according to a multivariate analysis, cardiopulmonaryreserve proved to be an important predictor of mortality. In a concluding statement Dr. Prentis says: "CPET is a non-invasive, sensitive and specific predictor ofsurvival following liver transplantation. However, furtherevaluation of its predictive value in larger cohorts is necessary." In a related editorial also published in LiverTransplantation, Dr. James Findlay from the Mayo Clinic inRochester, Minnesota writes: "While CPET is widely available there are similar preoperativeassessments such as the six-minute walking test that could also beused. Liver transplantation specialists have a duty to providecandidates with an accurate risk-benefit assessment and ensure thatscarce donor organs are used effectively. The findings of Prentisand colleagues are striking enough to merit further evaluation." Dr. Findlay suggests large, multi-center investigations of CPETthat include additional mortality indicators are necessary todevelop an outcome model that could be widely used in evaluatingcandidates for liver transplantation. Written by Petra Rattue Copyright: Medical News Today Not to be reproduced without permission of Medical News Today Additional References Citations. I am an expert from vacuum-circuit-breakers.com, while we provides the quality product, such as High Voltage Circuit Breakers , Vacuum Circuit Breakers Manufacturer, Medium Voltage Circuit Breaker,and more.
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