|
|
 |
|
|
Opioid-induced constipation in critical care patients may bereduced by methylnaltrexone by ferujkll sdff
|
|
|
Opioid-induced constipation in critical care patients may bereduced by methylnaltrexone by FERUJKLL SDFF
|
|
| Article Posted: 09/14/2012 |
| Article Views: 57 |
| Articles Written: 2023 - MORE ARTICLES FROM THIS AUTHOR |
| Word Count: 384 |
| Article Votes: 0 |
|
Opioid-induced constipation in critical care patients may bereduced by methylnaltrexone |
|
|
|
|
|
Business,Business News,Business Opportunities
|
|
Opioids are a mainstay of care in the critical care unit, but theiruse frequently causes constipation which can lead to adverse outcomes including delayed feeding andlater discharge from the ICU. Researchers from London, UK, andChicago, IL, have found that methylnaltrexone (MNTX), a peripheralopioid antagonist, may restore bowel function in critically illpatients. Their retrospective study appears in the March issue of Mayo Clinic Proceedings. "We found MNTX to be very effective in producing laxation whencompared with conventional laxatives in our critically illpatients.
MNTX was well tolerated and did not demonstrate any signsof reversing the effects of centrally mediated analgesia orprecipitate withdrawal," says lead author Parind B. Patel, MBBS,FRCA, Critical Care Medicine, Hammersmith Hospital, London. MNTXwas developed at the University of Chicago by Dr. Jonathan Moss.
Researchers reviewed 88 nonsurgical critical care patients in theirICU during a 10-week period. 15 of the patients suffered fromopioid induced constipation (OIC) within 72 hours of admission tothe ICU. 7 were managed with MNTX and 8 were managed withconventional therapy consisting of sodium picosulfate and glycerinsuppositories. The most striking result was the immediate effect of MNTX. Laxationoccurred within 24 hours in 6 of the 7 patients, compared with noneof the 8 patients in the conventional therapy group.
MNTX wasineffective in one patient with a large intra-abdominal hematoma.When this patient was excluded from the analysis, the MNTX-treatedpatients laxated within 7.8 hours vs. 96.0 hours for patients whoreceived conventional treatment. "We observed a clinically significant improvement in feeding anddecreased gastric residual volumes in our patients with MNTXtreatment," notes Dr. Patel.
"Although our study was too small todemonstrate statistical significance, the improvement in enteralfeeding suggests that further study is merited. The reduction inresidual volumes following MNTX was dramatic and facilitated earlytarget enteral feeding. There is a trend toward improved outcome,but our study was too small to document this statistically." The lack of suitable therapy has hampered study of bowel functionin the ICU. "Our findings demonstrate a potential role for MNTX inmanaging OIC in critically ill patients and suggest that a largercontrolled study in the ICU environment is merited," Dr. Patelconcludes.
Additional References Citations. I am Bag Making Machinery writer, reports some information about yellow rain coats , wooden mail boxes.
Related Articles -
yellow rain coats, wooden mail boxes,
|
Rate This Article  |
|
|
|
|
|
Do you Agree or Disagree? Have a Comment? POST IT!
| Reader Opinions |
|
|
|
|
|
|
|
|
|
| Author Login |
|
|
 |
Advertiser Login
ADVERTISE HERE NOW!
Limited Time $60 Offer!
90 Days-1.5 Million Views
|
|
TIM FAY
After 60-plus years of living, I am just trying to pass down some of the information that I have lea...more
|
|
|
|
|
LAURA JEEVES
At LeadGenerators, we specialise in content-led Online Marketing Strategies for our clients in the t...more
|
|
|
|
|
ALEX BELSEY
I am the editor of QUAY Magazine, a B2B publication based in the South West of the UK. I am also the...more
|
|
|
|
|
GENE MYERS
Author of four books and two screenplays; frequent magazine contributor. I have four other books "in...more
|
|
|
|
|
SUSAN FRIESEN
Located in the lower mainland of B.C., Susan Friesen is a visionary brand strategist, entrepreneur, ...more
|
|
|
|
|
STEPHEN BYE
Steve Bye is currently a fiction writer, who published his first novel, ‘Looking Forward Through the...more
|
|
|
|
|
SHALINI MITTAL
A postgraduate in Fashion Technology. Shalini is a writer at heart! Writing for her is an expression...more
|
|
|
|
|
ADRIAN JOELE
I have been involved in nutrition and weight management for over 12 years and I like to share my kn...more
|
|
|
|
|
JAMES KENNY
James is a Research Enthusiast that focuses on the understanding of how things work and can be impro...more
|
|
|
|
