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A new study has found encouraging results treating lab ratssuffering from Alzheimer's disease with polyphenols derived fromred wine. The research is important because it's a rare case wherethe wine compounds worked outside the petri dish. In the last fiveyears, medical research has focused on wine polyphenols as apotential preventative for cognitive decline, but there has beenlittle success with animal tests. This new study, from Mount Sinaiin New York, comes one step closer to making such therapy areality. In lab conditions, polyphenols have broken down amyloid-betaplaques, which clog up the brain's pathways in Alzheimer's. Inrodent testing, however, it becomes more of a challenge. Previousresearch finds that red wine-based supplements are often digestedin the intestine, moved to the liver and then metabolized withoutgreat benefits. In order to create a clinical product for the bodyto absorb, a biosynthetic polyphenol would need to be ingestedorally, nasally or subcutaneously to enter the bloodstream andtravel to the brain. There are other complications. As head researcher Dr. GiulioPasinetti, a neurologist and geriatric researcher at Mount Sinai,points out, grapes from California are different than grapes fromGreece. Red wine can contain polyphenols with very differentchemical structures. Finding the best red wine molecule combinationto direct toward human testing can be hit and miss. "It's arelatively new field, the focus on grapes in nutraceuticals, and itis so very complicated," Pasinetti told Wine Spectator . "The big problem is that the answers appear to be somewhere inred wine, but commercially available simulations, like grapepowders, are not nearly as powerful." For this study, reported in a recent issue of the Journal of Neuroscience , the Mount Sinai researchers administered several doses of redwine polyphenols catechin and epicatechin to lab rats. They foundwhen they altered the chemical structure from a polymer to a moresimple monomer, the polyphenols accumulated in the brain. The redwine compounds were administered in drinking water, which meansthey were absorbed early in the digestive process. It is the first time these chemicals were found in the brain,suggesting a possible preventative role, Pasinetti believes. Ratson the monomer combination not only showed fewer symptoms ofAlzheimer's, but also appeared to be more intelligent in severaltests. Pasinetti admitted that developing a possible therapy for peoplesuffering from Alzheimer's or other cognitive diseases will taketime. But Mount Sinai is using the results toward its clinicalresearch into aging and red wine consumption. So far, theresearchers have not found an adequate substitute for theresponsible consumption of red wine. And there are, from time totime, setbacks in the research that can delay the results. "Natureis unpredictable," Passinetti said. "Sometimes you can end up goingin the wrong direction.". The e-commerce company in China offers quality products such as China Rfid Card Readers , Door Exit Button Manufacturer, and more. For more , please visit Door Exit Button today!
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