LipoScience, Inc., a highly innovative diagnostic company that isadvancing patient care by developing high value proprietary bloodtests using nuclear magnetic resonance (NMR) technology, announcedpublication of a clinical study in the Journal of Clinical Lipidology demonstrating that in many people, low density lipoprotein (LDL) cholesterol ("bad" cholesterol) is a less accurate predictor of cardiovasculardisease (CVD) events than LDL particle number. "Additional studies should be conducted to estimate the potentialvalue of this information for the prevention of cardiovasculardisease in the general population." LDL cholesterol is transported in spherical LDL particles. Highlevels of LDL particles are a proven cause of plaque buildup in thearteries, which in turn leads to heart attacks and other CVD events. Clinicians historically have used the LDLcholesterol level, the amount of cholesterol carried within LDLparticles, to determine how much treatment, if any, a patientneeds. Controlling LDL levels with diet, exercise and LDL-loweringdrugs is thus a primary focus of CVD prevention efforts. |
"This paper provides additional evidence that measurement oflipoprotein particles in clinical practice might lead to betterrisk management and prevention of cardiovascular disease," saidDavid C. Goff, Jr., M.D., Ph.D., chair of the Department ofEpidemiology and Prevention at Wake Forest University BaptistMedical Center and an investigator in the study. "Additionalstudies should be conducted to estimate the potential value of thisinformation for the prevention of cardiovascular disease in thegeneral population. "In many patients, the standard cholesterol test may not besufficient to adequately manage LDL levels.
Patients who achieverecommended LDL-C goals may not have achieved correspondingly lowLDL-P levels and as a consequence, may need further LDL lowering,"said Dr. Goff. Researchers analyzed blood samples obtained at study onset from5,598 middle-aged men and women free of cardiovascular disease whoparticipated in the Multi-Ethnic Study of Atherosclerosis (MESA), aprospective observational study initiated and overseen by theNational Heart, Lung and Blood Institute. Participants werefollowed for a mean of 5.5 years for incident CVD events -including heart attack, coronary heart disease death, angina , stroke , stroke death or other artherosclerotic or CVD death.
Because the cholesterol content of LDL particles varies from personto person, there may be disagreement between LDL cholesterol andLDL particle levels. Of 319 total CVD events recorded, 159 occurredin persons with LDL cholesterol and LDL particle numbers thatdisagreed. The CVD risk of these individuals tracked with LDLparticle number regardless of levels of LDL cholesterol. LDLparticle levels were measured using LipoScience's NMRLipoProfile® test, a laboratory test that utilizes nuclearmagnetic resonance (NMR) spectroscopy to measure LDL and otherlipoprotein particles.
LDL particle information can help clinicianspersonalize and refine LDL treatment decisions, particularly tominimize residual risk in patients with low LDL cholesterol levels. Source: LipoScience, Inc. Additional References Citations.
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