Use of 10/66 dementia diagnosis criteria results in an increase inthe estimated incidence of dementia in middle-income countries,according to a study published online May 23 in The Lancet . WEDNESDAY, May 23 (HealthDay News) -- Use of 10/66 dementiadiagnosis criteria (10/66) results in an increase in the estimatedincidence of dementia in middle-income countries, according to astudy published online May 23 in The Lancet . To investigate the incidence of dementia, Martin Prince, M.D., fromKing's College London, and colleagues conducted a population-basedcohort study of 12,887 individuals aged 65 years or older residingin urban sites in Cuba, the Dominican Republic, and Venezuela, andin rural and urban sites in Peru, Mexico, and China. Three to fiveyears after cohort inception, incident dementia was ascertainedusing 10/66 and Diagnostic and Statistical Manual of Mental Disorders, FourthEdition ( DSM-IV ) criteria. Of the participants interviewed at baseline, the researchers foundthat 11,718 were free of dementia, 69 percent of whom werereinterviewed. |
During the resulting 34,718 person-years offollow-up, the incidence for 10/66 dementia was 1.4 to 2.7 timeshigher than the incidence for DSM-IV dementia, ranging from 18.2 to 30.4 per 1,000 person-years.Compared with those who were dementia-free, the risk of mortalitywas 1.56 to 5.69 times higher for individuals with dementia atbaseline. Based on 10/66 diagnostic criteria, increased incidenceof dementia correlated with increased age (hazard ratio [HR],1.67), and decreased incidence of dementia correlated with male sex(HR, 0.72) and higher education (HR, 0.89); no significantcorrelation was observed with occupational attainment (HR, 1.04; 95percent confidence interval, 0.95 to 1.13). "Our results provide supportive evidence for the cognitive reservehypothesis, showing that in middle-income countries as inhigh-income countries, education, literacy, verbal fluency, andmotor sequencing confer substantial protection against the onset ofdementia," the authors write. The 10/66 Dementia Research Group works closely with Alzheimer'sDisease International, which is partially funded by thepharmaceutical industry. Abstract Full Text (subscription or payment may be required) Editorial (subscription or payment may be required) Copyright © 2012 HealthDay.
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