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H1n1 vaccination during pregnancy shows unexpected benefits inlarge study - Velvet Stickers by he ni





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H1n1 vaccination during pregnancy shows unexpected benefits inlarge study - Velvet Stickers by
Article Posted: 04/29/2013
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H1n1 vaccination during pregnancy shows unexpected benefits inlarge study - Velvet Stickers


 
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Getting a flu shot during pregnancy provides unanticipated benefits to the baby,according to the authors of a large population-based studyexamining the issue. Specifically, the study showed that H1N1 vaccination during the pandemic was associated with asignificantly reduced risk of stillbirth, preterm birth andextremely small babies at birth. Researchers at the Ottawa Hospital Research Institute (OHRI), theCHEO Research Institute and the University of Ottawa (uOttawa) useddata from Ontario's birth record database, BORN, to examine 55,570single-child births that took place in Ontario during the H1N1pandemic. The resulting paper, " H1N1 Influenza Vaccination during Pregnancy and Fetal and Neonatal Outcomes," wasrecently published by the American Journal of Public Health.

The study shows that, compared to pregnant women who were notimmunized against H1N1, mothers who received the H1N1 vaccinationwere: 34% less likely to have a stillbirth, 28% less likely to deliver before 32 weeks, and 19% less likely to give birth to a child with a birth weight forgestational age in the bottom third percentile. "These are all significant results, but especially interesting isthe finding that the vaccinated mothers were one-third less likelyto have a stillborn child," says lead author Deshayne Fell, anepidemiologist for BORN Ontario. "This is one of the only studieslarge enough to evaluate the association between maternal fluvaccination and stillbirth - a very rare event." "What surprised me and the research team was the strength of theprotective benefits we found," says co-author Dr. Ann Sprague, theScientific Manager of BORN Ontario at the Children's Hospital ofEastern Ontario (CHEO) Research Institute.

The study also found no increase in adverse outcomes forH1N1-vaccinated mothers and their babies during the weeks beforeand just after birth, also referred to as the perinatal period. "The findings of this study are very helpful," says co-author Dr.Mark Walker, a Senior Scientist at OHRI, a High-Risk Obstetricianat The Ottawa Hospital, and a Professor and Tier One Research Chairin Perinatal Research at the University of Ottawa. "Pregnant women are generally very, very careful about what theyput into their bodies. For health-care providers like me, such alarge-scale study that shows no adverse perinatal outcomesresulting from the H1N1 flu vaccine will be extremely helpful whendiscussing maternal vaccination." Of all the single-child births recorded from November 2009 to April2010, 42% of the women received the H1N1 vaccination, which makesthe findings robust. BORN - the Better Outcomes Registry & Network- collects data from all births in Ontario.

In order to conduct theresearch for this study, questions about H1N1 vaccination wereadded to the database in advance of the H1N1 vaccine becomingavailable. BORN includes demographic data that allowed the researchteam to correct for smoking, education and income; however, as withany population-based study, it may not be possible to account forall influencing factors. Additional References Citations.

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