Amazines Free Article Archive - Sunday, January 26, 2020
Read about the most recent changes and happenings at
Log into your account or register as a new author. Start submitting your articles right now!
Search our database for articles.
Subscribe to receive articles emailed straight to your email account. You may choose multiple categories.
View our newest articles submitted by our authors.
View our most top rated articles rated by our visitors.
* Please note that this is NOT the ARTICLE manager
Add a new EZINE, or manage your EZINE submission.
Add fresh, free web content to your site such as newest articles, web tools, and quotes with a single piece of code!
Home What's New? Submit/Manage Articles Latest Posts Top Rated Article Search
Subscriptions Manage Ezines
 Article Archive
 Advertising (133326)
 Advice (160999)
 Affiliate Programs (34736)
 Art and Culture (73698)
 Automotive (145681)
 Blogs (75065)
 Boating (9841)
 Books (17218)
 Buddhism (4125)
 Business (1328658)
 Business News (426321)
 Business Opportunities (366271)
 Camping (10962)
 Career (72737)
 Christianity (15846)
 Collecting (11637)
 Communication (115053)
 Computers (241955)
 Construction (38999)
 Consumer (49681)
 Cooking (17061)
 Copywriting (6568)
 Crafts (18205)
 Cuisine (7539)
 Current Affairs (20394)
 Dating (45782)
 EBooks (19687)
 E-Commerce (48205)
 Education (185263)
 Electronics (83503)
 Email (6395)
 Entertainment (159843)
 Environment (28938)
 Ezine (3039)
 Ezine Publishing (5446)
 Ezine Sites (1550)
 Family & Parenting (110901)
 Fashion & Cosmetics (196391)
 Female Entrepreneurs (11842)
 Feng Shui (130)
 Finance & Investment (310291)
 Fitness (106205)
 Food & Beverages (62874)
 Free Web Resources (7938)
 Gambling (30229)
 Gardening (25112)
 Government (10514)
 Health (629634)
 Hinduism (2205)
 Hobbies (44047)
 Home Business (91561)
 Home Improvement (251375)
 Home Repair (46146)
 Humor (4825)
 Import - Export (5453)
 Insurance (45130)
 Interior Design (29560)
 International Property (3485)
 Internet (190991)
 Internet Marketing (146346)
 Investment (22826)
 Islam (1167)
 Judaism (1356)
 Law (80520)
 Link Popularity (4592)
 Manufacturing (20842)
 Marketing (98791)
 MLM (14136)
 Motivation (18213)
 Music (27005)
 New to the Internet (9480)
 Non-Profit Organizations (4048)
 Online Shopping (129617)
 Organizing (7803)
 Party Ideas (11856)
 Pets (38079)
 Poetry (2234)
 Press Release (12676)
 Public Speaking (5618)
 Publishing (7523)
 Quotes (2407)
 Real Estate (126633)
 Recreation & Leisure (95294)
 Relationships (87564)
 Research (16159)
 Sales (80325)
 Science & Technology (110227)
 Search Engines (23462)
 Self Improvement (153103)
 Seniors (6233)
 Sexuality (35943)
 Small Business (49288)
 Software (82996)
 Spiritual (23468)
 Sports (116087)
 Tax (7658)
 Telecommuting (34068)
 Travel & Tourism (307502)
 UK Property Investment (3121)
 Video Games (13428)
 Web Traffic (11728)
 Website Design (56833)
 Website Promotion (36574)
 World News (1000+)
 Writing (35776)
Author Spotlight

Jim Turner is a USA based author of Legal issues related to estate planning, will & trust , busyness...more

In regards to earning money online, everybody wishes to, and everybody strives to, but not many end ...more

I have been involved in nutrition and weight management for over 12 years and I like to share my kn...more

My Name is Anish Sah, I am an Internet Marketing and SEO Expert, Social Media Guru and young Entrepr...more

Financial analyst and author writing on economy and business. ...more

Alzheimer's disease may spread by 'jumping' from one brain regionto another - Precision Plastic Mol by fdhjkl rfghjtkl

Article Author Biography
Alzheimer's disease may spread by 'jumping' from one brain regionto another - Precision Plastic Mol by
Article Posted: 06/03/2013
Article Views: 67
Articles Written: 2148
Word Count: 581
Article Votes: 0
AddThis Social Bookmark Button

Alzheimer's disease may spread by 'jumping' from one brain regionto another - Precision Plastic Mol

Business,Business News,Business Opportunities
For decades, researchers have debated whether Alzheimer's disease starts independently in vulnerable brain regions at differenttimes, or if it begins in one region and then spreads toneuroanatomically connected areas. A new study by ColumbiaUniversity Medical Center (CUMC) researchers strongly supports thelatter, demonstrating that abnormal tau protein, a key feature ofthe neurofibrillary tangles seen in the brains of those withAlzheimer's, propagates along linked brain circuits, "jumping" fromneuron to neuron. The findings, published in the online journal PloS One , open new opportunities for gaining a greater understanding ofAlzheimer's disease and other neurological diseases and fordeveloping therapies to halt its progression, according to seniorauthor Karen E. Duff, PhD, professor of pathology (in psychiatryand in the Taub Institute for Research on Alzheimer's Disease andthe Aging Brain) at CUMC and at the New York State PsychiatricInstitute. Alzheimer's disease, the most common form of dementia , is characterized by the accumulation of plaques (composed ofamyloid-beta protein) and fibrous tangles (composed of abnormaltau) in brain cells called neurons.

Postmortem studies of humanbrains and neuroimaging studies have suggested that the disease,especially the neurofibrillary tangle pathology, begins in theentorhinal cortex, which plays a key role in memory. Then asAlzheimer's progresses, the disease appears in anatomically linkedhigher brain regions. "Earlier research, including functional MRI studies in humans, havealso supported this pattern of spread," said study coauthor ScottA. Small, MD, professor of neurology in the Sergievsky Center andin the Taub Institute for Research on Alzheimer's Disease and theAging Brain at CUMC. "But these various findings do notdefinitively show that Alzheimer's spreads directly from one brainregion to another." To look further into this issue, the CUMC researchers developed anovel transgenic mouse in which the gene for abnormal human tau isexpressed predominantly in the entorhinal cortex.

The brains of themice were analyzed at different time points over 22 months to mapthe spread of abnormal tau protein. The researchers found that as the mice aged, the abnormal human tauspread along a linked anatomical pathway, from the entorhinalcortex to the hippocampus to the neocortex. "This pattern very muchfollows the staging that we see at the earliest stages of humanAlzheimer's disease," said Dr. Duff.

The researchers also found evidence suggesting that the abnormaltau protein was moving from neuron to neuron across synapses, thejunctions that these cells use to communicate with each other. The findings of the study have important implications for therapy. "If, as our data suggest, tau pathology starts in the entorhinalcortex and emanates from there, the most effective approach may beto treat Alzheimer's the way we treat cancer - through early detection and treatment, before it has a chance tospread," said Dr. Small. "The best way to cure Alzheimer's may beto identify and treat it when it is just beginning, to haltprogression.

It is during this early stage that the disease will bemost amenable to treatment. That is the exciting clinical promisedown the road." Treatments could conceivably target tau during it extracellularphase, as it moves from cell to cell, added Dr. Duff. "If we canfind the mechanism by which tau spreads from one cell to another,we could potentially stop it from jumping across the synapses -perhaps using some type of immunotherapy. This would prevent thedisease from spreading to other regions of the brain, which isassociated with more severe dementia." Additional References Citations.

We are high quality suppliers, our products such as Precision Plastic Mold Manufacturer , China Rubber Injection Mold for oversee buyer. To know more, please visits Rubber Injection Mold.

Related Articles - Precision Plastic Mold Manufacturer, China Rubber Injection Mold,

Email this Article to a Friend!

Receive Articles like this one direct to your email box!
Subscribe for free today!

 Rate This Article  
Completely useless, should be removed from directory.
Minimal useful information.
Decent and informative.
Great article, very informative and helpful.
A 'Must Read'.


Do you Agree or Disagree? Have a Comment? POST IT!

 Reader Opinions 
Submit your comments and they will be posted here.
Make this comment or to the Author only:
*Your email will NOT be posted. This is for administrative purposes only.
Comments: *Your Comments WILL be posted to the AUTHOR ONLY if you select PRIVATE and to this PUBLIC PAGE if you select PUBLIC, so write accordingly.
Please enter the code in the image:

 Author Login 
Register for Author Account


Advertiser Login


   Limited Time $60 Offer!
   90  Days-1.5 Million Views  


Great Paranormal Romance


Steve Bye is currently a fiction writer, who published his first novel, ‘Looking Forward Through The...more

At LeadGenerators, we specialise in content-led Online Marketing Strategies for our clients in the t...more

Author of four books and two screenplays; frequent magazine contributor. I have four other books "in...more

Stevert Mckenzie, Travel Enthusiast. ...more

Susan Friesen, founder of the award-winning web development and digital marketing firm eVision Media...more

Rev Bresciani is the author of two Christian books. One book is an important and concisely written b...more

I am not a writer nor am I trying to become a writer. I am an average person with average intelligen...more

Kiranpreet (Kiran) Kaur, D.D.S., who received her Doctor of Dental Surgery degree from the prestigio...more

Steve Burgess is a freelance technology writer, a practicing computer forensics specialist as the pr...more

Joanna Morgan has a huge passion for making money online from home and enjoys traveling around the w...more

HomeLinksAbout UsContact UsTerms of UsePrivacy PolicyFAQResources
Copyright © 2020, All rights reserved.
Some pages may contain portions of text relating to certain topics obtained from under the GNU FDL license