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Mice give clue to 'self-repairing skin' - China Human Hair Top Closure - Double Sided Tape Hair Ext by fdhjkl rfghjtkl
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Mice give clue to 'self-repairing skin' - China Human Hair Top Closure - Double Sided Tape Hair Ext by FDHJKL RFGHJTKL
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Article Posted: 07/16/2013 |
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Mice give clue to 'self-repairing skin' - China Human Hair Top Closure - Double Sided Tape Hair Ext |
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Scar free healing in mice may give clues to human skinrepair, BBC News has reported. The broadcaster says thatscientists are interested in figuring out how the healing takesplace and if it could apply to people . While some species are known to be able to regenerate their skinand, in some cases, entire body parts, it is thought that thisability is limited in mammals. However, the researchers who carriedout this study had heard reports that a particular mouse called theAfrican spiny mouse does have this ability. The researchers trapped a number of these mice in central Kenya andtook them to a laboratory for further testing. They found that themice have skin that tears away easily, enabling them to escapepredators. The mice regenerate the lost skin, and even grow newhair, instead of forming a scar. The study challenges some of the conventional wisdom surroundingwound healing and regenerative processes in mammals. It is hopedthat new understanding of these biological processes could lead tonew treatments for skin damage, scalding and burns in humans. Butthis research is at a very early stage and whether these processeswill one day help the regeneration of human tissue remains to beseen. Where did the story come from? The study was carried out by researchers from the Universities ofFlorida, Wyoming and Nairobi. No information regarding the fundingwas listed in the publication. The study was published in the peer-reviewed journal Nature. This research was covered quite appropriately by the media, withthe BBC being careful to emphasise that working out what ishappening and then trying to transfer the findings to people islikely to be a long journey . What kind of research was this? This was an animal study that examined the wound healing ability ofa specific type of mouse, called the African spiny mouse. Several animals are able to lose (or autotomise ) sections oftissue or whole limbs in order to escape capture by predators.After this tissue is lost, it is either: replaced through regeneration (as when salamanders a type oflizard regrow limbs), or is gone for good with a scar forming to seal the wound (as seen inmost mammals) This research looked at an unusual example of a mammal theAfrican spiny mouse which is capable of regenerating lost tissueinstead of simply forming a scar over the wound. What did the research involve? The researchers first set out to confirm anecdotal evidence(unverified word-of-mouth reports) that the African spiny mousedoes indeed autotomise its skin to evade predators. Once they haddone this, they then examined the healing properties of thesewounds, studying how quickly they healed as well as the processesinvolved. They also examined exactly how the tissue regenerated. While most adult mammals are unable to regenerate skin andassociated tissue after being injured, previous studies have shownthat a few animals (including rabbits) are able to do so. To see ifthe African spiny mice exhibited the same capability, theresearchers punched 4mm holes in the ears of the mice, and examinedwhat types of tissues were regenerated. What were the basic results? The researchers found that handling of the African spiny mice oftenled to the tearing away of skin from the back, resulting in largeopen wounds. These wounds ranged from small areas to the loss ofnearly 60% of the skin from the back. The researchers found thatthese wounds healed quickly, and that the mouse s characteristicspiny hairs regrew as well, completely covering the wound. When examining the wound healing process, the researchers foundthat, as with wound healing in other mammals, a scab formed quicklyand bleeding stopped. However, new cells called epithelial cellsformed on top of the wound after three days, more quickly than seenin other adult mammals. Also, as is seen in other rodents, thewound healed mainly by contracting, or shrinking the wound size.After 17 days, 95% of the wound closure had been due to thiscontraction of the tissue. This is unlike other species, in which a thick web of collagen islaid down over the wound in order to seal it off and protect thebody from infection, resulting in scarring. Because the mouse skinhealed so quickly, less collagen was deposited, resulting in novisible scarring. When they examined tissue regeneration after the loss of skin fromthe back, the researchers found that new skin cells and hairfollicles (the cells embedded in the skin, from which hairs grow)were also regenerated in the deposited sections of collagen. The African spiny mice were able to regenerate the lost ear tissue,growing new skin, hair follicles, fat cells, muscle and cartilageinstead of forming scars. This finding was similar to previousresults in rabbits. Finally, during the ear experiment, the researchers found evidenceto suggest that the tissue regeneration was due to the formation ofa blastema, which is a group of cells that are responsible for theregrowth of lost limbs in salamanders. How did the researchers interpret the results? The researchers say their results suggest that the African spinymouse uses a balance of scarring and tissue regeneration in woundhealing. They say this indicates that mammals may have a highercapacity for regenerations than was previously believed . Conclusion This was an early stage animal study that describes an unusualphenomenon in mammal wound healing and provides a basis for futurestudies. These studies are likely to investigate the molecularprocesses that underpin the skin and hair regeneration in theAfrican spiny mouse. The researchers say that future investigations will focus on howthe mice are able to control scar formation, and that this may shed light on how regeneration and scarring can be balanced inthe face of infection and inflammation. They also say that thisshould allow for further research into tissue regeneration inmammals, and that the African spiny mouse may prove quite useful infinding ways to promote tissue regeneration instead of scarring. When the molecular pathways that underlie the wound healingprocesses seen in African spiny mice are more thoroughlyunderstood, researchers may begin to study whether they can beapplied to wound healing and regenerative medicine in people.However, it is likely to be a long time until this intriguing pieceof research leads to medical applications. Analysis by Bazian . Edited by NHS Choices . Follow Behind the Headlines on twitter . I am an expert from China Human Hair Top Closure, it usually analyzes various kinds of industry situation, such as China Human Hair Top Closure, and many more. Welcome to visit! We are high quality suppliers, our products such as China Human Hair Top Closure , Double Sided Tape Hair Extensions for oversee buyer. To know more, please visits Indian Remy Hair Extension.
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