A report in the January issue of Archives of General Psychiatry , one of the JAMA/Archives journals states, that in adolescents with diagnosed schizophrenia and other psychoses gray matter volume seems to decrease andcerebrospinal fluid in the frontal lobe increases compared tohealthy adolescents without psychosis. According to background information in the article: "Progressive loss of brain gray matter (GM) has been reported inchildhood-onset schizophrenia; however, it is uncertain whetherthese changes are shared by pediatric patients with differentpsychoses." Dr. Celso Arango of the Hospital General Universitario GregorioMara n in Madrid, Spain, and his team evaluated theprogression of patients' changes in the brain during thefirst-episode of early-onset psychosis, as well as the relationshipto diagnosis and prognosis at two-year follow-up. The study wasconducted at six child and adolescent psychiatric units in Spain. Of all participants, 25 were diagnosed with schizophrenia, 16patients had bipolar disorder and 20 participants suffered from other psychoses, whilst 70healthy participants served as a control group. The researchersperformed a brain magnetic resonance imaging (MRI) scan in allparticipants at study baseline and at the two-year follow-up. The findings revealed that that those diagnosed with schizophreniadisplayed a greater volume loss in gray matter and an increase incerebrospinal fluid in the frontal lobe at the 2-year follow-upcompared with participants in the control group. Furthermore, theydiscovered that changes for total brain gray matter and leftparietal gray matter were substantially different in participantsof schizophrenic group compared with those in the control group. Progressive brain volume changes in certain areas from participantsin the schizophrenic group were linked to markers of poorerprognosis, like a longer period of hospitalization during follow-upand less improvement in negative symptoms. Greater left frontalgray matter volume loss was also linked to more weeks ofhospitalization, whilst the severity of negative symptoms wasrelated to an increase of cerebrospinal fluid in the schizophrenicgroup. The researchers did not detect any important changes betweenpatients in the bipolar group compared with those in the controlgroup. They observed that longitudinal brain changes in patients ofthe control group proved consistent with the expected patterndefined for healthy adolescents. The researchers summarize their findings, writing: "In conclusion, we found progression of gray matter volume lossafter a two-year follow-up in patients who ended up with adiagnosis of schizophrenia but not bipolar disease compared withhealthy controls. Some of these pathophysiologic processes seem tobe markers of poorer prognosis. To develop therapeutic strategiesto counteract these pathologic progressive brain changes, futurestudies should focus on their neurobiological underpinnings." Written by Petra Rattue Copyright: Medical News Today Not to be reproduced without permission of Medical News Today Additional References Citations. I am an expert from led-spotlightbulbs.com, while we provides the quality product, such as Cell Phone Faceplate Covers Manufacturer , Led Downlight Replacement, E27 Led Bulb,and more.
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