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Hpv linked oropharyngeal cancer rates rise dramatically by 123wert sdfsf

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Hpv linked oropharyngeal cancer rates rise dramatically by
Article Posted: 08/09/2013
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Hpv linked oropharyngeal cancer rates rise dramatically

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In the 1980s just over 16% of patients with oropharyngeal cancers tested positive to HPV, compared to over 70% during the lastdecade, researchers reported in the Journal of Clinical Oncology . The authors add that if the rise in incidence continues at itspresent pace, the incidence of oropharyngeal cancers will overtakethat of cervical cancer. HPV stands for human papillomavirus Oropharyngeal cancer is cancer which develops in the tissue of the oropharynx, themiddle part of the throat, including the base of the tongue,tonsils, the soft palate, and the walls of the pharynx. According to prior studies, oropharyngeal cancers can be dividedinto: HPV-negative cancers - which are usually linked to alcohol andtobacco use HPV-positive cancers - which are associated with some types of HPV,a sexually transmitted virus. Those with this type of oropharyngealcancer are usually younger than HPV-negative cancer patients.

Patients generally have better survival rates with this type ofcancer. Said senior author Maura Gillison, MD, PhD, professor of medicineand Jeg Coughlin Chair of Cancer Research at The Ohio StateUniversity Comprehensive Cancer Center in Columbus, wrote: "We used to think of oropharyngeal cancer as one cancer, and now weknow the disease is comprised of two biologically andepidemiologically distinct cancers. This new understanding willincreasingly enable us to improve and better personalize care forpatients with each form of the disease." The team had previously demonstrated that survival rates andincidence for oropharyngeal cancers rose considerably in Americabetween 1973 and 2004, while incidence rates for other cancers ofthe head and neck, such as oral cavity, dropped during the sameperiod. They tested 271 archived oropharynx cancer tissue samples from5,755 patients for HPV infections.

The samples came from threeregistries in Los Angeles, Iowa and Hawaii that had been collectedbetween 1984 and 2004. Using several molecular assays they demonstrated that thepercentage of oropharyngeal cancers that were HPV-positive roseconsiderably during that period, from 16.3% between 1984 and 1989to 72.7% between 200 and 2004. In 1988, there were 0.8 cases of HPV-positive cancers per 100,000people, compared to 2.6 in 2004 - a 225% increase. As smoking ratesduring the same period had dropped, HPV-negative oropharyngealcancer rates dropped by 50%.

By 2020, HPV-positive oropharyngeal cancers will be the major formof cancer for the head and neck, and the leading HPV-linked cancer,overtaking cervical cancer if current trends continue, the authorsadded. Gillison said: "These increases may reflect increases in sexual behavior,including increases in oral sex." Gillison explained that between 90% and 95% of HPV-positiveoropharyngeal cancers are caused by the same HPV type which iscurrently targeted by the vaccines administered to prevent cervicalcancer - HPV 16. Gillison wrote: "But with HPV vaccines, we have a great opportunity to potentiallyprevent oropharynx cancers in future generations - including inboys and men - but studies need to be done to evaluate the efficacyof HPV vaccines in preventing oral HPV infections." First author Anil Chaturvedi, PhD, said: "Prospective studies are needed to investigate the natural historyof oral HPV infection because little is currently known about itsincidence and persistence, any modifiable risk factors involved inits persistence and opportunities for screening." Gregory Masters, MD, American Society of Clinical Oncology (ASCO),Cancer Communications Committee member and head and neck cancerspecialist, wrote: "This is a significant study because it clarifies the growing roleof HPV as a causative agent in head and neck cancer. The findingscould have particular relevance for HPV vaccine administrationpolicy and recommendations for those at risk for HPV-relatedcancers. We now have stronger evidence to tie behaviors to theincidence of different variations on this one cancer type.

What is interesting is that these findings about the incidence of oral cancer are in line with the simultaneous changes in sexual behaviorpatterns and the decline in smoking. We are encouraged by what theavailability of HPV vaccines may be able to do to prevent thesecancers now that we have a clearer understanding of causation, butwe also have more work to do for those cancers unrelated to HPV." Written by Christian Nordqvist Copyright: Medical News Today Not to be reproduced without permission of Medical News Today Additional References Citations.

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