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Naringin belongs to the group of flavonoids. Pure naringin is a yellowish powder. Naringin is a conjugate of a sugar molecule with naringenin. The structure of naringin is very similar to that of hesperidin.Naringin is mainly found in grapefruits. It is the compound that gives grapefruit its typical bitter flavour. Naringin may be instrumental in inhibiting cancer-causing compounds and thus may have potential chemotherapeutic value. Studies have also shown that naringin interferes with enzymatic activity in the intestines and, thus, with the breakdown of certain drugs, resulting in higher blood levels of the drug. A number of drugs that are known to be affected by the naringin in grapefruit include calcium channel blockers, estrogen, sedatives, medications for high blood pressure, allergies, AIDS, and cholesterol-lowering drugs. Caffeine levels and effects of caffeine may also be extended by consuming grapefruit or grapefruit juice. While the effect of naringin on the metabolism of a drug can increase the drug's effectiveness, it can also result in dosages that are inadvertently too high. Therefore, it's best not to take any drugs with grapefruit juice unless the interaction with the drug is known. In addition, the effects of drinking grapefruit juice is cumulative, which means that if you drank a glass of grapefruit juice daily with your medication for a week, the drug interaction would be stronger at the end of the week than at the beginning. Research on Naringin shows the following effects: 1. Protects against toxins in chemotherapy drugs and the environment 2. Enhances lipid metabolism 3. Enhances ethanol metabolism 4. Reduces negative effects of ethanol intake 5. Acts as a free radical scavenger 6. Reduces cytotoxicity 7. Acts as an antioxidant 8. Acts as an anti-apoptotic 9. Protect from carcinogenic matter 10. May reduce risk of atherosclerosis 11. Significantly inhibits LDL oxidation 12. Used in the treatment of gastric lesions 13. Inhibits the Sindbis neurovirulent virus 14. Reduces total cholesterol levels 15. Protects plasma vitamin E levels 16. Prevents hypercholesterolemia 17. Is anti-atherogenic
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