Nexium act as an proton pump inhibitor

Mechanism of action :

Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose-related up to a daily dose of 20 to 40 mg and leads to inhibition of gastric acid secretion.

Indications :

• Treatment of Gastroesophageal Reflux Disease (GERD)

• Healing of Erosive Esophagitis : It is indicated for the short-term treatment (4 to 8 weeks) in the healing and symptomatic resolution of diagnostically confirmed erosive esophagitis. For those who have not healed after 4 to 8 weeks of treatment, an additional 4 to 8 week course of NEXIUM may be considered.

• Maintenance of Healing of Erosive Esophagitis : This drug is indicated to maintain symptom resolution and healing of erosive esophagitis.

• Symptomatic Gastroesophageal Reflux Disease : This medicine is indicated for short-term treatment (4 to 8 weeks) of heartburn and other symptoms associated with GERD in adults and children 1 year or older

• Risk Reduction of NSAID-Associated Gastric Ulcer : It is indicated for the reduction in the occurrence of gastric ulcers associated with continuous NSAID therapy in patients at risk for developing gastric ulcers.

• H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence : Triple Therapy (NEXIUM plus amoxicillin and clarithromycin): NEXIUM, in combination with amoxicillin and clarithromycin, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or history of within the past 5 years) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.

• dizziness, confusion;
• fast or uneven heart rate;
• jerking muscle movements;
• jittery feeling;
• muscle cramps, muscle weakness or limp feeling;
• cough or choking feeling; or
• Seizure (convulsions).

This drug may potentially interact with a number of other medicines. Some of these possible Nexium drug interactions may involve the following:

• Certain antifungals, such as: Fluconazole , Itraconazole , Ketoconazole, Posaconazole, Voriconazole, Cilostazol ,Clopidogrel ,Dasatinib, Diazepam ,Digoxin
• Certain diuretics, such as: Bumetanide ,Chlorothiazide ,Chlorthalidone thacrynic acid ,Furosemide ,Hydrochlorothiazide Metolazone ,Torsemide ,Erlotinib
• Iron supplements or medications: Mesalamine ,Methotrexate ,Rifampin
• Some protease inhibitors, such as: Atazanavir ,Nelfinavir ,Saquinavir

Esomeprazole may increase the risk for bone fractures, especially with longer use, higher doses, and in older adults. To prevent bone loss/fracture, by taking such as calcium (such as calcium citrate) and vitamin D supplements.

During pregnancy, this medication should be used only when clearly needed.

Dosage :

• Gastroesophageal Reflux Disease (GERD)
• Healing of Erosive Esophagitis : 20 mg or 40 mg : Once Daily for 4 to 8 Weeks*
• Maintenance of Healing of Erosive Esophagitis : 20 mg : Once Daily
• Symptomatic Gastroesophageal Reflux : 20 mg : Once Daily for 4 Weeks
• Pediatric GERD

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