Citalopram Hydrobromide is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other available antidepressant agents. It is a racemic bicyclic phthalane derivative designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile. The molecular formula is C20H22BrFN2O,molecular weight is 405.35, and CAS NO is 59729-32-7. Citalopram Hydrobromide, USP occurs as a fine, white to off-white powder. It is sparingly soluble in water and soluble in ethanol. It is available as tablets. Citalopram Hydrobromide is used to treat depression. It may improve your energy level and feelings of well-being. It is known as a selective serotonin reuptake inhibitor (SSRI). This medication works by helping to restore the balance of a certain natural substance (serotonin) in the brain.This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This medication may also be used to treat other mental conditions (such as obsessive-compulsive disorder, panic disorder). It may also be used to treat hot flashes that occur with menopause. Sexual dysfunction is often a side effect with SSRIs. Specifically, common side effects include difficulty becoming aroused, lack of interest in sex, and anorgasmia (trouble achieving orgasm). Genital anesthesia, loss of or decreased response to sexual stimuli, and ejaculatory anhedonia are also possible. Although usually reversible, in some people these sexual side effects become permanent after the drug has been completely withdrawn.This is known as post-SSRI sexual dysfunction. One study showed however that when remission of major depressive disorder is achieved, quality of life is reported to be higher in spite of sexual side effects. Citalopram Hydrobromide theoretically causes side effects by increasing the concentration of serotonin in other parts of the body (e.g., the intestines). Other side effects, such as increased apathy and emotional flattening, may be caused by the decrease in dopamine release that is associated with increased serotonin. It is also a mild antihistamine, which may be responsible for some of its sedating properties. Common side effects of Citalopram Hydrobromide include drowsiness, insomnia, nausea, weight changes, vivid dreaming, frequent urination, decreased sex drive, anorgasmia, dry mouth, increased sweating, trembling, diarrhea, excessive yawning, and fatigue. Less common side effects include bruxism, vomiting, cardiac arrhythmia, blood pressure changes, dilated pupils, anxiety, mood swings, headache, and dizziness. Rare side effects include convulsions, hallucinations,severe allergic reactions and photosensitivity. If sedation occurs, the dose may be taken at bedtime rather than in the morning. There is data suggesting that Citalopram Hydrobromide may cause nightmares. Overdosage of Citalopram Hydrobromide may result in vomiting, sedation, disturbances in heart rhythm, dizziness, sweating, nausea, tremor, and rarely amnesia, confusion, coma, or convulsions. Overdose deaths have occurred, sometimes involving other drugs but also with this medicine as the sole agent. Citalopram Hydrobromide and N-desmethylcitalopram may be quantized in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients or to assist in a medicolegal death investigation. Blood or plasma Citalopram Hydrobromide concentrations are usually in a range of 50-400 µg/L in persons receiving the drug therapeutically, 1000-3000 µg/L in patients who survive acute overdosage and 3–30 mg/L in those who do not survive.It is the most dangerous of SSRIs in overdose. Want to learn more information about Citalopram Hydrobromide, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals.
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