Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, buckthorn and Japanese knotweed. It can also be isomers in botanical extracts. It is being studied as a potential agent that could reduce the impact of type 2 diabetes. It is a potent selective inhibitor of the enzyme 11ß-HSD1. In studies in obese mice, emodin limits the effect of glucocorticoids and may therefore ameliorate diabetes and insulin resistance. Pharmacological studies have demonstrated that emodin(CAS NO:518-82-1) when isolated from rhubarb exhibits anti-cancer effects on several human cancers, including human pancreatic cancer. Emodin in rhubarb extracts may also have neuroprotective properties against glutamate toxicity. Aloe-emodin is a variety of emodin found in Socotrine, Barbados, and Zanzibar aloes, but not in Natal aloes. It is also shown to block cytomegalovirus infections as well as herpes simplex. Research is currently being performed in this area. Emodin may help reduce inflammation and has been shown to destroy certain types of cancer cells. This natural supplement may be helpful in the treatment of specific medical conditions, including cancer, constipation, inflammation, microbial infections or peptic ulcers, explains the Memorial Sloan-Kettering Cancer Center in New York City. Before beginning treatment, talk with a doctor about potential emodin side effects. While taking emodin, patients can develop stomach-related side effects because of treatment, explains Drugs.com, a peer-reviewed drug information website for consumers. Stomach upset symptoms can include nausea or vomiting, which can be uncomfortable and may contribute to a decreased appetite in certain patients. Consider taking emodin after eating a small snack or meal to prevent the development of these stomach-upset side effects. Emodin is digested by naturally-occurring bacteria within the large intestine, reports Drugs.com, where it is converted to a substance called aglycone. Aglycone acts to regulate the way the large intestine absorbs and secretes fluids from the foods that a patient ingests and may increase the rate at which the muscular intestinal wall contracts. As a result, patients taking this type of supplement can experience sudden or severe diarrhea as a side effect of treatment. Diarrhea is characterized by frequent, watery bowel movements that can occur in conjunction with abdominal cramping, bloating or pain. These symptoms of diarrhea can also contribute to sensations of nausea in certain patients taking this medicine. Prolonged use of anthraquinones, such as emodin, have been associated with an increased risk of kidney or liver damage in certain patients, explain health officials at both Memorial Sloan-Kettering Cancer Center and Drugs.com. Though the cause of this damage is unclear, these side effects may lead to acute renal failure if left untreated. Further studies are required for researchers to determine the direct link between emodin use and kidney and liver damage. Want to learn more information about Emodin, you can access the guidechem.com. Guidechem Chemical Network providing the most complete information of the chemical industry.
Related Articles -
Emodin, guidechem, 518-82-1,
|