"This was certainly an unexpected finding," saidprincipal investigator Robert J. Schneider, PhD, the Albert SabinProfessor of Molecular Pathogenesis, associate director fortranslational research and co-director of the Breast Cancer Programat NYU Langone Medical Center. "It is rather uncommon for onegene to have two very different and very significant functions thattie together control of aging and inflammation. The two, if notregulated properly, can eventually lead to cancer development. It'san exciting scientific find." The study, funded by the National Institutes of Health, appearsonline ahead of print May 24 in Molecular Cell and is scheduled for the July 13 print issue. For decades, the scientific community has known that inflammation,accelerated aging and cancer are somehow intertwined, but theconnection between them has remained largely a mystery, Dr.Schneider said. What was known, due in part to past studies bySchneider and his team, was that a gene called AUF1 controlsinflammation by turning off the inflammatory response to stop theonset of septic shock. But this finding, while significant, did notexplain a connection to accelerated aging and cancer. When the researchers deleted the AUF1 gene, accelerated agingoccurred, so they continued to focus their research efforts on thegene. Now, more than a decade in the making, the mysterysurrounding the connection between inflammation, advanced aging andcancer is finally being unraveled. The current study reveals that AUF1, a family of four relatedgenes, not only controls the inflammatory response, but alsomaintains the integrity of chromosomes by activating the enzymetelomerase to repair the ends of chromosomes, therebysimultaneously reducing inflammation, preventing rapid aging andthe development of cancer, Dr. Schneider explained. "AUF1 is a medical and scientific trinity," Dr. Schneidersaid. "Nature has designed a way to simultaneously turn offharmful inflammation and repair our chromosomes, therebysuppressing aging at the cellular level and in the wholeanimal." With this new information, Dr. Schneider and colleagues areexamining human populations for specific types of geneticalterations in the AUF1 gene that are associated with theco-development of certain immune diseases, increased rates of agingand higher cancer incidence in individuals to determine exactly howthe alterations manifest and present themselves clinically. I am an expert from chromepistonrod.com, while we provides the quality product, such as Steel Guide Rod , China Induction Hardened Bar, Chrome Piston Rod,and more.
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