|
Using blood, urine and tissue analysis of a unique mouse model, ateam led by UC Davis researchers has identified several proteins asdiagnostic biomarkers and potential therapeutic targets for kidney cancer . Subject to follow-up validation testing, inhibition of theseproteins and several related pathways holds promise as a form oftherapy to slow the growth of kidney tumors. In a paper published online in the journal Cancer Research, the researchers found high concentrations of specific proteinsthat point to alterations in three sequences of chemical reactionsknown as biochemical pathways of mice implanted with human kidneycancer cells. The findings suggest that cancerous tumors modulatethe pathways, which in turn makes these pathways potentialtherapeutic targets. Nicotinamide and cinnamoylglycine, which were altered as asignature of one of the pathways, are just two of approximately2,000 chemicals, or metabolites, that the human body produces.Metabolites, referring to any substance produced by metabolism, area reflection of the body's processes in real time. The field ofstudy, known as metabolomics, enables researchers to discoverbiomarkers and to identify novel therapeutic targets. The study used metabolomics techniques and instrumentation tosimultaneously examine chemicals in two biofluids (urine and serum,or blood) as well as tissue from kidney cancer mice models. Seekingto describe the utility of these fluids as tumor indicators, theyfound that serum metabolomics analysis is the most accurate proxyof chemical changes that are related to kidney cancer. "It's exciting to report that our identification of severalimportant metabolic processes may well result in the discovery ofdiagnostic markers and new therapeutic targets for kidney cancers ," said lead author Robert H. Weiss, a professor in the UC DavisDivision of Nephrology, Department of Internal Medicine. Currently,there are no tests to easily identify kidney cancer and currenttreatments are not always successful, so these markers will beimportant tools for detection and new treatments of the disease. For the study, researchers transplanted human kidney cancer cellsinto a mouse model capable of growing human tumors. Researcherscompared the metabolites identified in the implanted mice againstthose in a control group of mice that had surgery, but no cancercells implanted. If further research with mouse models demonstrates that inhibitionof the newly identified targets works in therapy, then preparationfor human trials will be a next step. "This research represents collaboration among many kinds ofexperts, all of whom are concerned that kidney cancer patients havetoo few treatment options, which often have debilitating sideeffects," said Weiss, who serves as chief of nephrology at theSacramento Veterans' Administration Medical Center in addition tohis work at UC Davis. Additional References Citations. I am an expert from african-lacefabrics.com, while we provides the quality product, such as China Embroidered Net Lace , African Embroidery Lace Fabric, African Net Lace Fabrics,and more.
Related Articles -
China Embroidered Net Lace, African Embroidery Lace Fabric,
|
