Amazines Free Article Archive
www.amazines.com - Wednesday, December 02, 2020
Read about the most recent changes and happenings at Amazines.com
Log into your account or register as a new author. Start submitting your articles right now!
Search our database for articles.
Subscribe to receive articles emailed straight to your email account. You may choose multiple categories.
View our newest articles submitted by our authors.
View our most top rated articles rated by our visitors.
* Please note that this is NOT the ARTICLE manager
Add a new EZINE, or manage your EZINE submission.
Add fresh, free web content to your site such as newest articles, web tools, and quotes with a single piece of code!
Home What's New? Submit/Manage Articles Latest Posts Top Rated Article Search
Google
Subscriptions Manage Ezines
CATEGORIES
 Article Archive
 Advertising (133434)
 Advice (161175)
 Affiliate Programs (34757)
 Art and Culture (73748)
 Automotive (145650)
 Blogs (75228)
 Boating (9844)
 Books (17221)
 Buddhism (4128)
 Business (1329025)
 Business News (426382)
 Business Opportunities (366354)
 Camping (10967)
 Career (72752)
 Christianity (15849)
 Collecting (11638)
 Communication (115068)
 Computers (241942)
 Construction (38921)
 Consumer (49685)
 Cooking (17068)
 Copywriting (6653)
 Crafts (18205)
 Cuisine (7544)
 Current Affairs (20419)
 Dating (45889)
 EBooks (19696)
 E-Commerce (48224)
 Education (185303)
 Electronics (83507)
 Email (6407)
 Entertainment (159839)
 Environment (28927)
 Ezine (3039)
 Ezine Publishing (5451)
 Ezine Sites (1550)
 Family & Parenting (110929)
 Fashion & Cosmetics (196424)
 Female Entrepreneurs (11847)
 Feng Shui (131)
 Finance & Investment (310448)
 Fitness (106332)
 Food & Beverages (62917)
 Free Web Resources (7940)
 Gambling (30223)
 Gardening (25151)
 Government (10533)
 Health (629686)
 Hinduism (2206)
 Hobbies (44055)
 Home Business (91582)
 Home Improvement (251106)
 Home Repair (46178)
 Humor (4832)
 Import - Export (5453)
 Insurance (45105)
 Interior Design (29585)
 International Property (3485)
 Internet (191008)
 Internet Marketing (146479)
 Investment (22849)
 Islam (1167)
 Judaism (1356)
 Law (80455)
 Link Popularity (4595)
 Manufacturing (20858)
 Marketing (99001)
 MLM (14136)
 Motivation (18221)
 Music (27012)
 New to the Internet (9496)
 Non-Profit Organizations (4048)
 Online Shopping (129631)
 Organizing (7805)
 Party Ideas (11853)
 Pets (38069)
 Poetry (2234)
 Press Release (12683)
 Public Speaking (5635)
 Publishing (7528)
 Quotes (2407)
 Real Estate (126636)
 Recreation & Leisure (95398)
 Relationships (87678)
 Research (16171)
 Sales (80337)
 Science & Technology (110257)
 Search Engines (23488)
 Self Improvement (153227)
 Seniors (6236)
 Sexuality (35949)
 Small Business (49283)
 Software (83015)
 Spiritual (23475)
 Sports (116092)
 Tax (7659)
 Telecommuting (34067)
 Travel & Tourism (307869)
 UK Property Investment (3121)
 Video Games (13428)
 Web Traffic (11748)
 Website Design (56838)
 Website Promotion (36596)
 World News (1000+)
 Writing (35790)
Author Spotlight
ELLISEN WANG

I'm Ellisen, nice to meet you! Obviously you're here because you want to know who I am. Wel...more
PUSHPA SRIVASTAVA

Pushpa Srivastava is an SEO strategist that helps online business owners figure out how to grow thei...more
CACEY TAYLOR

Im just a man who likes to be happy and see others happy. Im into home business, sports, family, and...more
ELLIOT CHANG

Financial analyst and author writing on economy and business. ...more
AVINASH KABRA

Avinash Kabra is a young & dynamic Technopreneur, Digital Marketer, Blogger, Foodie and Travel Enthu...more


Stem Cells and Cancer by suie sun





Article Author Biography
Stem Cells and Cancer by
Article Posted: 07/11/2014
Article Views: 99
Articles Written: 522
Word Count: 1140
Article Votes: 0
AddThis Social Bookmark Button

Stem Cells and Cancer


 
Health
The concept that cancer arises from stem cells was very first proposed more than 150 years ago because the embryonal rest theory of cancer. Even so, by the starting from the 20 th century, the embryonal rest theory of cancer was discarded, along with the hypothesis that cancer arises from de-differentiation became usually accepted. Then, about 50 years ago, research on cancers of germinal tissue (teratocarcinomas) re-established the principles that cancer arises from stem cytes, and that cancer might be treated by induction of differentiation (differentiation therapy). Nevertheless, teratocarcinomas had been regarded exceptions towards the rule, as well as the de-differentiation theory of origin remained typically accepted for many cancers till the 1980 s. Then research around the cellular origin of cancer for the duration of experimental chemical hepatocarcinogenesis showed that hepatocellular cancer didn't arise from de differentiation of hepatocytes, as was usually believed, but rather from maturation arrest of cytes within the hepatocyte lineage. The re-emergence in the cell theory of cancer preceded the present excitement in cancers.

During the last ten years, differentiation therapy has been applied with wonderful good results to cancer from the blood cytes (leukemias) by inactivation from the signaling pathways that enable the leukemic transit-amplifying to continue to proliferate and not die (maturation arrest). Differentiation therapy of cancer is now proposed by way of the usage of tiny inhibitory molecules or inhibitory RNAs (iRNAs) to block the signals that sustain 'stemness' to ensure that the leukemic tissues are permitted to differentiate. Standard chemotherapy, radiotherapy, and anti-angiogenic therapies act around the carcinomoa. When these therapies are discontinued, the cancer will re- kind in the therapy-resistant cancer. Effective differentiation therapy of cancer cells would force these cells to differentiate, in order that they could no longer re-establish the cancer.

The cell of origin of all tissues is named a stem cell. From this a single all other cells arise. The fertilized ovum may be the primordial for all the tissues on the human physique. The instant progeny in the primordia are embryonic stem cells, which, in turn, give rise to tissues. It truly is from these tissues that most cancers arise.

Standard tissue and cancer tissue include exactly the same populations:

Stem cells,

Transit-amplifying cells,

And terminally differentiated cells.

Standard tissue renewal and development of cancer are each achieved by division from the transit-amplifying cells. Typically, the stem cells of each standard tissue and cancers are fairly handful of in quantity, in comparison with the transit-amplifying as well as the terminally differentiated cells, and they usually do not take part in proliferation. The proliferating ones of each cancers and standard tissue will be the transit-amplifying cells. Cancer tissue differs from regular tissue in that the transit-amplifying cells accumulate in cancer, whereas in standard tissue differentiate in order that they no longer divide (terminal differentiation).

One from the greatest examples in the regular cellular lineage as well as in the contribution of maturation arrest to cancer is skin. The pluripotent skin epidermal stem cells are positioned inside the bulb on the hair follicle. The epidermis-committed stem cells are positioned within the basal layer on the skin (germinativum) and are considerably fewer in quantity than the transit-amplifying carcinoma is situated inside the spinosum layer. Maturation is achieved via the accumulation of cytokeratin, which becomes prominent within the granular layer. The granules include cytokeratin. The cytoplasm on the cells inside the granular layer becomes filled with these granules and sooner or later the cells drop their structure, forming the outer layer of acellular keratin, identified because the corneum.

Skin cancers arise by maturation arrest at different levels of differentiation from the epidermis. Maturation arrest on the primitive skin progenitor tissue inside the bulge in the hair follicle offers rise to trichoepitheliomas, which differ in cellular differentiation but typically include each keratitic and basal regions, at the same time as clear cells characteristic of hair follicle. Cells inside the basal layer might give rise to basal cell carcinomas or squamous cell carcinomas. Overexpression of Ras inside the far more hugely determined basal cells from the skin produces squamous cell carcinoma, and induced expression in the c-myc gene within the non-proliferative suprabasal cells reactivates the cell cycle and results in hyperplasia (papillomas). Papillomas don't progress to invasive tumors. Examination from the cellular populations in skin cancer demonstrates that the malignant cells also can differentiate, but that the proliferative transit-amplifying cells from the cancer usually do not uniformly do so, as opposed to regular skin tissue.

Handy Hint: This quick article is just hoping to blow your mind away from the subject about stem cells, all the tips through this short content aim to educate only and in case you would love to study further regarding this matter, do a simple search concerning "stem cells" on any search engine and you'll be granted loads of ideas which are helpful for you.

The distinction in between typical tissue renewal and cancer development is the fact that the amount of cells which can be developed by cellular division in regular tissue primarily equals the amount of cells that terminally differentiate inside a provided time period, to ensure that the total quantity of cells remains continuous. In contrast, in cancers, the proliferating transit-amplifying cells don't all terminally differentiate, as well as the variety of cells inside the cancer increases. These in each typical tissue renewal and cancer development consist of a little fraction of cellular population which can be not actively proliferating, and that fraction serves as a cellular reserve population. When a tissue stem cell divides, it offers rise to one particular daughter cyte that remains a stem cell and 1 daughter cell that starts the method of differentiation by becoming a transit-amplifying cell (asymmetric division); as a result, the stem cells stay inside the tissue for lengthy periods of time, basically the lifetime from the organism. The amount of cells inside a cancer increases with time, since the transit-amplifying cells give rise to two cells that don't mature and retain the prospective to divide (symmetric division) or the mature cells usually do not die or each.

Attempts to culture cells from regular tissues and cancers had been nicely underway inside the 1950 s, and there had been even some early research suggesting that regular tissues include stem cells with malignant possible. It was discovered that malignant cells may be derived from regular rat myocardium (fibroblasts) in the event the cells had been cultured for any extended time in anaerobic situations. Most regular tissue cells don't survive below these circumstances, and standard tissue includes uncommon cells. using the possible for malignant modify beneath chosen culture circumstances.

It is little things, such as this idea which might aid you in your particular search concerning anti aging. So, sit down and decide which avenue and mean would be better for you to take.

Related Articles - Stem, Cells,

Email this Article to a Friend!

Receive Articles like this one direct to your email box!
Subscribe for free today!

 Rate This Article  
Completely useless, should be removed from directory.
Minimal useful information.
Decent and informative.
Great article, very informative and helpful.
A 'Must Read'.

 

Do you Agree or Disagree? Have a Comment? POST IT!

 Reader Opinions 
Submit your comments and they will be posted here.
Make this comment or to the Author only:
Name:
Email:
*Your email will NOT be posted. This is for administrative purposes only.
Comments: *Your Comments WILL be posted to the AUTHOR ONLY if you select PRIVATE and to this PUBLIC PAGE if you select PUBLIC, so write accordingly.
 
Please enter the code in the image:



 Author Login 
LOGIN
Register for Author Account

 

Advertiser Login

 

ADVERTISE HERE NOW!
   Limited Time $60 Offer!
   90  Days-1.5 Million Views  

 

Great Paranormal Romance


STEVERT MCKENZIE

Stevert Mckenzie, Travel Enthusiast. ...more
PAUL RICE

hello everyone l been on the net since 2000 and enjoy my work l work as an affiliate and also have w...more
GENE MYERS

Author of four books and two screenplays; frequent magazine contributor. I have four other books "in...more
JASON NG

Jason Ng has a huge passion for the health and fitness industry as he strongly believes that having ...more
LAURA JEEVES

At LeadGenerators, we specialise in content-led Online Marketing Strategies for our clients in the t...more
TIM FAY

I am not a writer nor am I trying to become a writer. I am an average person with average intelligen...more
DAMIAN POWELL

Demonstrated exceptional leadership in the government and private sector at an executive level. Skil...more
XTAGE XIXTEEN

My name is Kingsley Chihozie. Am from the western part of Africa, Nigerian. Am a graduate of Abia St...more
CHRIS BURTON

I am an International Corporate Consultant specialising in the bespoke formation of offshore compani...more
SUSAN FRIESEN

Susan Friesen, founder of the award-winning web development and digital marketing firm eVision Media...more

HomeLinksAbout UsContact UsTerms of UsePrivacy PolicyFAQResources
Copyright © 2020, All rights reserved.
Some pages may contain portions of text relating to certain topics obtained from wikipedia.org under the GNU FDL license