|
When autologous (self-donated) lung-derived mensenchymal stem cells (LMSCs) were transplanted endoscopically into 13 adult femalesheep modeled with emphysema , post-transplant evaluation showed evidence of tissue regenerationwith increased blood perfusion and extra cellular matrix content.Researchers concluded that their approach could represent apractical alternative to conventional stem cell-based therapy fortreating emphysema. The study is published in Cell Transplantation (21:1), now freely available on-line.* "Mensenchymal stem cells are considered for transplantation becausethey are readily available, highly proliferative and displaymulti-lineage potential," said study corresponding author Dr.Edward P. Ingenito of the Brigham and Women's Hospital Division ofPulmonary and Critical Care Medicine. "Although MSCs have beenisolated from various adult tissues - including fat, liver and lungtissues - cells derived from bone marrow (BM) have therapeuticutility and may be useful in treating advanced lung diseases, suchas emphysema." However, according to the authors, previous transplantationstudies, many of which used an intravenous delivery method, haveshown that BM-MSCs have been only marginally successful in treatinglung diseases. Further, therapeutic responses in those studies havebeen limited to animal models of inflammatory lung diseases, suchas asthma and acute lung injury. To try and answer the questions surrounding the utility of BM-MSCsfor treating advanced emphysema, a disease characterized by tissuedestruction and loss of lung structural integrity, for this studythe researchers isolated highly proliferative, mensenchymal cellsfrom adult lung parenchyma (functional tissue) (LMSCs) and used anendoscopic delivery system coupled with a scaffold comprised ofnatural extracellular matrix components. "LMSCs display efficient retention in the lung when deliveredendobronchially and have regenerative capacity through expressionof basement membrane proteins and growth factors," explained Dr.Ingenito. However, despite the use of autologous cells, only a fraction ofthe LMSCs delivered to the lungs alveolar compartment appeared toengraft. Cell death likely occurred because of the failure of LMSCsto home to and bind within their niche, perhaps because the nichewas modified by inflammation or fibrosis. These cells areattachment-dependent and failure to attach results in cell death." Their findings did suggest, however, that LMSCs were capable ofcontributing to lung remodeling leading to documented functionalimprovement rather than scarring 28 days post transplantation. "Although the data is from a small number of animals, results showthat autologous LMSC therapy using endoscopic delivery and abiocompatible scaffold to promote engraftment is associated withtissue remodeling and increased perfusion, without scarring orinflammation," concluded Dr. Ingenito. "However, questionsconcerning mechanism of action and pattern of physiologicalresponse remain topics for future investigation." "The impact of mesenchymal stem cells derived from autologous lungtissue demonstrated in this study, suggests that transplantation ofthese cells could prove to be an important factor in the treatmentof emphysema, though further studies are required" said Dr. Amit N.Patel, director of cardiovascular regenerative medicine at theUniversity of Utah and section editor for Cell Transplantation. Additional References Citations. The e-commerce company in China offers quality products such as Toy Lamp , Spectrometer, and more. For more , please visit China LED manufacturers today!
Related Articles -
Toy Lamp, Spectrometer,
|
