 Cap Rocaltrol
Composition: Each capsule contains : Calcitriol IP 0.25mg Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. Low blood levels of calcium may cause bone disease. Calcitriol is in a class of medications called vitamins. It works by helping the body to use more of the calcium found in foods or supplements. Mechanism of action:
This drug increases blood calcium levels ( [Ca2+] ) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium thus reducing the loss of calcium in the urine. It also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, which in turn activates osteoclasts. Indications: This drug is prescribed for
Drug interaction:
Cholestyramine
Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitamins; as such it may impair intestinal absorption of this drug. Phenytoin/Phenobarbital
The coadministration of phenytoin or phenobarbital will not affect plasmaconcentrations of this drug, but may reduce endogenous plasma levels of 25(OH)D3 by accelerating metabolism. Since blood level of calcitriol will be reduced, higher doses of this drug may be necessary if these drugs are administered simultaneously.
Thiazides
Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. Some reports have shown that the concomitant administration of thiazides with Rocaltrol (calcitriol) causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary. Digitalis
Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias . Ketoconazole
Ketoconazole may inhibit both synthetic and catabolic enzymes of this medication. Reductions in serum endogenous calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. Corticosteroids
A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. Phosphate-Binding Agents
Since Rocaltrol (calcitriol) also has an effect on phosphate transport in theintestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration. Vitamin D
Since calcitriol is the most potent active metabolite of vitamin D3, pharmacological doses of vitamin D and its derivatives should be withheld during treatment with this drug to avoid possible additive effects and hypercalcemia. Calcium Supplements
Uncontrolled intake of additional calcium-containing preparations should be avoided. Magnesium
Magnesium-containing preparations (eg, antacids) may causehypermagnesemia and should therefore not be taken during therapy with this medicine by patients on chronic renal dialysis. Side effects: Stop using this medicine and if you have a serious side effect such as: - some weakness, headache, drowsiness;• feeling sick ,vomiting, stomach pain, constipation;
- loss of appetite;
- dry mouth, increased thirst;
- metallic taste in mouth;
- urinating more than usual;
- fast, slow, or uneven heart rate;
- changes in behavior;
- muscle tissue discomforttenderness, bone.
Dosage: An oral calcitriol dose for hypocalcemia is 0.25 micrograms per day, which can be increased by 0.25 micrograms per dosage at four- to eight-week intervals. Storage:
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Hi everyone, this is Martin Adam from USA. I am completed P.HD in pharmacy. I do lots of work in pharmacy but now I am working in Onlinegenericpills.com. I also write blog on all health related product like Kamagra Jelly, Abortion pill online in USA, Xenical, Gabapentin, Buy Zyvox online in USA etc.
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