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Displaying 1 to 4 of 4 articles |
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Articles by lisa feng |
1. proteins influence the pharmacokinetics and pharmacodynamics of doxorubicin
November 17, 2013
Doxorubicin is just a DNA-BINDING, topoisomerase II inhibitor, that is one of the most efficient chemotherapy drugs in cancer therapy. Nevertheless, innate or acquired resistance to doxorubicin in tumours is frequent, leading to illness development and treatment failure. Numerous systems for doxorub...
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2. HDACis able to binding unique organic objectives
November 17, 2013
Inhibition of SOD1 was proven to recover the awareness in ovarian cancer cells and to deal with MDR cancers since, for instance, SOD1 is just a therapeutic goal of TM. It's been noted that chemotherapy-induced generation of ROS is usually linked with service of the p38 and JNK MAPK signaling pathway...
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3. Pulmonary embolus was thought to be accountable for one death
November 15, 2013
its acceptance by the FDA, there has been six instances of sudden deaths in patients treated with Romidepsin. Pulmonary embolus was thought to be accountable for one death, as the other five cases were related to sudden cardiac arrest. Handling this cardiotoxicity becomes essential as numerous HDACi...
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4. The development of OG-L002 through clinical trials has-been the subject
November 15, 2013
Treatment was stopped in six patients because of the frequency of significant side effects, such as thrombocytopenia, contamination and QT interval prolongation. Disappointingly, none of the people in these trials showed partial or complete response to therapy, but the prevalence of drug-induced sid...
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