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During pregnancy, women are counseled to refrain from consumingcertain types of foods, beverages and medications in order to avoidjeopardizing the health and development of the fetus. In fact, theAmerican Pregnancy Association has a list of a dozen items theyrecommend expectant mothers omit from their diets. However, thereare some additions, such as folic acid, that, when taken beforeand/or during pregnancy, can actually reduce the risk of birthdefects and other disorders.1 Research presented at the Era of Hopeconference, a scientific meeting hosted by the Department ofDefense Breast Cancer Research Program (BCRP), reveals findingssuggesting that if an expectant mother increases her consumption offoods high in certain fatty acids or nutrients during herpregnancy, she can potentially reduce the risk of breast cancer in her female offspring. The research delves into breast cancer risk reductions attributedto the fetus when the mother, while pregnant, increases omega 3fatty acids within her diet or consumes dietary methyl nutrients(methionine, choline, folate and vitamin B12). Some findingshypothesize that these diet augmentations may even prevent breastcancer from ever developing in the offspring. "This is exciting and intriguing research," said Captain MelissaKaime, M.D., Director of the Congressionally Directed MedicalResearch Programs (CDMRP), under which the BCRP is managed. "To beable to reduce the risk and possibly prevent this devastatingdisease before birth is an incredible notion; the BCRP is proud tosupport research with such potential." Maternal Consumption of Omega 3 Fatty Acids to Reduce Breast CancerRisk in Offspring Principal Investigator: Philippe T. Georgel, PhD, MarshallUniversity Maternal dietary alterations, including increasing the consumptionof omega 3 fatty acids, may reduce the risk of breast cancer to thefetus by causing epigenetic changes in utero and later throughnursing. These changes may alter gene expression permanently, achange referred to as imprinting. Researchers at MarshallUniversity conducted a study to investigate whether having a dietrich in omega 3s while pregnant would result in changes to fetalmammary gland gene expression, thereby reducing the chance thatfemale offspring would later develop breast cancer. In this study, there was a reduced incidence of mammary gland cancer observed for the offspring of mice that, while pregnant andnursing, consumed a diet containing canola oil, rich in omega 3,compared with the offspring of mice that, while pregnant andnursing, consumed a diet containing corn oil rich in omega 6 fattyacids. Reviewing the gene expression profiles of both groups showedthat many genes related to cancer development differed between thetwo groups. Significant differences in the patterns of twoimportant epigenetic markers were also observed. "Pregnant women should be mindful of what they consume since theirdiet may incite epigenetic changes that could impact thedevelopment of their offspring, not just in utero but also for timeto come," said Dr. Philippe Georgel, Marshall University."Additional research continues, as we seek to elucidate the effectof diet on breast cancer-specific gene expression." In Utero Exposure to Dietary Methyl Nutrients and Breast CancerRisk in Offspring Principal Investigator: Chung S. Park PhD, North Dakota StateUniversity Links are being drawn to complete mammary gland development of themother during pregnancy and reduction in breast cancer risk in herdaughters. Supplementing the mother's diet with lipotropicnutrients (methionine, choline, folate and vitamin B12) is thoughtto increase methyl metabolism which stimulates the full developmentof the mammary gland, thereby inducing an epigenetic imprint in themammary gland of the fetus and decreasing its breast cancer risk.Investigators at North Dakota State University are researching thislink with the overall objective of determining the extent to whichsupplementing diets with methyl nutrients during pregnancy reducesthe offspring's overall breast cancer susceptibility. The study looked at 45 pregnant rats and randomized them into twogroups: one to receive a control and the other to be fed amethyl-supplemented diet. Once the pups were born, they wereseparated into three additional groups depending on the feedingregime of their mother. When the female pups reached a specificage, they were exposed to a chemical that induced breast cancer andresearchers charted when the first tumor appeared and measured alltumor sizes and volumes. Results demonstrated that the offspringfrom the methyl-supplemented diet group showed a decrease in tumorincidence and growth when compared to the control group. Also, theyhad fewer tumors and fewer tumors that multiplied. "The conclusions of this study suggest that we may be able toprevent the development of breast cancer in daughters of women atrisk for breast cancer by supplementing the mother's diet duringpregnancy," said Dr. Chung Park, North Dakota State University. "Welook forward to exploring this study further to strengthen theimplications of these initial findings." Additional References Citations. We are high quality suppliers, our products such as China Toughened Safety Glass , Borosilicate Float Glass Manufacturer for oversee buyer. 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