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Film Package Yi is a rapidly developing Preparation Technology. By Drugs Coated clothing, can significantly improve the appearance of tablet cores to improve the stability of tablet cores, highlighting the quality, particularly through Film coating To control drug release effect. Film coating the key to success is the use of a good film coating Accessories . A complete set of film coating accessories play a major film roles include polymer materials, plasticizers, sunscreens and pigments. Businesses often need to be purchased separately three or four or more accessories, and then explored through experiments rough coating ratio, in the production process, a good amount of calculation, turn the material to Solvent , The mixing before use. However, premixed accessories to simplify the cumbersome process. Film coating premix can contain all the necessary accessories, and has the optimal ratio, the amount that users only need to take film coating premix, to mix directly in the solvent after mixing can use, get a higher quality coating. Stomach coating To Stomach coating process of preparing, for example, 1 kg piece of the core for general Stomach color film coating, 3% of normal weight calculation formula coating material is about: hydroxyl propyl methyl Fiber Su ( HP MC) 18 g, poly Glycol 400 (PEG400) 3 grams, 9 grams of pigment, water, 220g. The traditional process is 18 g HPMC pre-weighed 180 grams by adding water, stirring until dissolved to clarify, add 3 g PEG400, fully mixing a solution of A. While another 40 grams of water added to the pigment, mix thoroughly dispersed into solution B. After mixing two solutions will continue to stir as the final coating solution. Before and after this process requires at least 2 to 3 hours. But the use of film coating premix, just 30 grams of premix added 220 g water, stirring after 45 minutes can be used, greatly simplifying the process, reducing time and effort. enteric coated Many enteric coated for premixed accessories are included polyvinyl acetate phthalate Ethylene Ester (PVAP), cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP), Acrylic acid Resins and other enteric Polymer And include diethyl phthalate, Lemon Acid ethyl ester plasticizer three, and anti-viscosity Talcum powder (Talc) and so on. After solution preparation and spray coating, coating by controlling the thickness, can easily achieve pH values of the release of drug dependence. To color water-based enteric CRYL-EZE, for example, the use of EudragitL100-55 as the main film-forming material, and adding a number of unique ancillary components, using a special formulation process is an efficient, simple, enteric coating system quickly. The direct use of the traditional preparation of methacrylic acid copolymer coating solution preparation process takes 110 minutes, and this enteric coated premix preparation process requires only 25 to 35 minutes, greatly simplify the process, fully embodies the pre- Mixed accessories efficient features. Sustained-release coating Using spray coating technology, the chip core is wrapped on the ethyl cellulose (EC) or acrylic resin film can get sustained release effect. In addition to coating the composition of its main film-forming prescription material, it can also pre-accession dibutyl, triglycerides, triethyl citrate and other plasticizers, HPMC, PEG and other porogen, and the stabilizer . U.S. Colorcon Inc. Surelease, FMC Corporation Aquacoat, R? Hm company RudragitNE30D, all belong to this type of aqueous dispersion coating products. Them by controlling the thickness or adjusting the amount of porogen to achieve the desired release effect. Chlorpheniramine Surelease for example, sustained-release pellets with (from 18 to 20 mesh) of coating, using GlattG PC G-3 Coating Machine Control material temperature 42 , spray pressure 1.5 bar, spray rate is about 25 grams / minute, the coating process of coating weight gain by controlling the thickness of the film can be easy to make preparations with sustained release effect. Add some water-soluble material can also adjust the release curve to achieve optimal release of the results. The e-commerce company in China offers quality products such as metal slitting cutters Manufacturer , China aluminum slitting, and more. For more , please visit sheet metal cutting machine today!
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