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As early as 9:00 Pharmaceutical: September 11 Pharmaceutical News Summary and Comment HC pharmaceutical industry network In recent years, Traditional Chinese medicine New oral dosage forms are progressing rapidly, mainly concentrated in the immediate-release dosage form, Slow release formulations, timing and location of release dosage forms release dosage form, and Pharmaceutical Excipients Preparation in the modern playing an increasingly important role. Effervescent tablet of Chinese medicine Chinese medicine in recent years developed a new dosage form, because effervescent Accessories Variety and amount of large, require special attention to the choice of accessories. In general, the new agents select the appropriate accessories should follow the following principles: First, to understand Pharmaceutical Excipients Performance, functionality, specifications, stability, and its incompatibility with applications and other content. Excipients such as moisture absorption, drug compatibility, mobility, solubility, viscosity. Second, to understand the nature of the drug itself (physical chemistry, biology and other properties). Polymorphs such as drugs, heat, humidity, light, pH sensitivity, solubility, in vivo stability. Third, agents have to be according to the process used to select medical supplements. These agents are mainly direct compression process, wet granulation, dry compression process, fluidized bed granulation, coating, spray granulation, etc., different production processes need to choose the right accessories. Fourth, pay attention to the drug dosage. Dose is generally divided into high dose and low dose. For the high dose, usually the problem is drugs and the necessary accessories are made of pills too, does not meet the requirements, it is necessary to select superior accessories to reduce the amount of accessories. For the low dose, the trace of drug in preparation of the uniform is the biggest problem. Fifth, the administration forms. Such as tablets, capsules, granules, powder, pellets, Pills, etc.. Sixth, the drug release characteristic. Such as immediate release, sustained release, controlled release (time, location) and so on. Effervescent tablet of Chinese medicine especially for children, the elderly and patients can not swallow solid dosage forms, drug rapid onset, bioavailability, and easy to carry. The Effervescent Tablets addition to the main drug and effervescent excipients, but also contain other excipients such as granulating agent (adhesives and wetting agents), diluent, flavoring agents, sweeteners, lubricants, defoamers such as coloring agents, these excipients in the formulation forming a very important role play. Effervescent tablet excipients choice in addition to considering these few principles, but also need to pay attention to the following questions: One commonly used effervescent acid source. Effervescent tablets are commonly used source of citric acid, tartaric acid, fumaric acid, adipic acid, malic acid. The citric acid is concerned, it is soluble in water, good taste, but has a strong moisture absorption, at 65% to 75% relative humidity, can absorb large amounts of water production and storage process, often caused by sticky red, particles difficult to dry, easy to slice up and other issues. Therefore, the production plant should control the temperature and humidity; storage should be used with good moisture-proof airtight containers. Second, effervescent tablets common source base. Common alkali source with sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, etc. Among them, sodium carbonate, sodium bicarbonate, potassium bicarbonate is most commonly used. The mechanism is the source of alkali and acid reaction of carbon dioxide. Third lubricant. Preparation of the effervescent tablet lubricant plays an important role, such as poor choice can affect the preparation and characteristics of products. Select water-soluble lubricant oral effervescent general, the most commonly used is polyethylene glycol 6000, which normally takes after smashing through 160 mesh used in the total amount of more than 5% by weight, excessive use will increase the sticky red. SDS, sodium dodecyl sulfate with foaming effect, but affect the clarity, the general need. L-leucine good lubrication, the dosage of 5% of the total weight before use sieving, drying, disadvantage is more expensive. Sodium benzoate has been used aspirin effervescent tablets, the dosage of 5% of the total weight. Sodium oleate, sodium chloride, sodium acetate limited lubrication. In addition, the sodium chloride can be used as protective agents cited. Fourth, fillers, binders, blowing agents. Oral effervescent common fillers for the lactose, mannitol, sucrose, glucose and other water-soluble excipients, adhesives are used such as ethanol, is best not to join the foam, so as not to affect the effervescent appearance. Fifth, flavoring agents, sweeteners, flavors, coloring. Oral effervescent adding an appropriate amount of flavoring agents, sweeteners and flavors, can improve taste, increase patient compliance. There are peppermint flavoring agent, menthol, artificial vanilla, cinnamon and various fruit, the general amount of 0.5% to 3% in order to spray dry flavoring agent was most satisfactory. "China Pharmacopoeia "Received the 2005 edition contains sweeteners have Asipatan, Stevia factors; flavor with sweet orange, lemon, orange flavor, apple, pineapple and other flavors can be chosen to use. Adding a small amount of oral effervescent tablets with national discretion Food Additive Standard color, quantity should be specified. I am an expert from sf1pk.com, while we provides the quality product, such as China investment castings , gravity die casting, gravity die casting,and more.
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