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Fosamax is the most widely known drug prescribed for bone diseases such as osteoporosis and osteitis deformans, otherwise known as Paget’s disease. A lot of reports, both good and bad, have been brought including the link between Fosamax and esophageal cancer which FDA recently reviewed. While Fosamax has been widely received by the many, its cousin drug – Fosamax Plus D – deserves equal attention for its probably equivalent effect. The generic counterpart of Fosamax Plus D is alendronate sodium and cholecalciferol. Alendronate belongs to the biphosphonate group of drugs which interferes with the bone cycle particularly during bone resorption. Bone loss is condensed while apparently bone density is enhanced. On the contrary, cholecalciferl, is the partially active form of vitamin D after being synthesized by sunlight. It is later translated in to calcitriol which is the active calcium regulating hormone. This is the hormone responsible for increasing the level of calcium in the blood by: Increasing the absorption of calcium from the small intestine Decreasing the calcium excretion to the urine by the kidney Increasing the release of calcium into the blood from bone Fosamax Plus D has been approved by the Food and Drug Administration (FDA) to be given as treatment for osteoporosis in menopausal women and also in men to increase their bone density. But, patients suffering from diseases where there is excessive production of vitamin D, e.g. leukemia, giving this drug is contraindicated. Moreover, this is also not recommended to patients with renal insufficiency or renal failure. Instructions on the dosage of the drug is similar to that with Fosamax. Take the drug first thing in the morning after rising up and at least 30 minutes before your first meal, drink or other drugs. Drink Fosamax Plus D with a full glass of plain water – not mineral water – and do not lie down or recline for the next 30 minutes. Because alendronate is also found in Fosamax Plus D, it may yield the same side effects as with Fosamax primarily for that reason. In addition, there may be a need to check the level of vitamin D in your blood as this drug contains a week worth of recommended vitamin D intake and overdose of this vitamin may occur. These concerns need to be discussed with your physician. Because it contains analogous substance with Fosamax, Fosamax D may also yield severe adverse events such as a typical fracture in the femur and death of jawbone tissue. Several people have filed a Fosamax lawsuit against Merck, the drug manufacturer.
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