|
|
 |
|
|
Bpa could affect reproductive capabilities, cause infection of theuterus by wwy yrj
|
|
|
Bpa could affect reproductive capabilities, cause infection of theuterus by WWY YRJ
|
|
| Article Posted: 06/23/2012 |
| Article Views: 78 |
| Articles Written: 1412 - MORE ARTICLES FROM THIS AUTHOR |
| Word Count: 590 |
| Article Votes: 0 |
|
Bpa could affect reproductive capabilities, cause infection of theuterus |
|
|
|
|
|
Business,Business News,Business Opportunities
|
|
CINCINNATI—Researchers at the University of Cincinnati havefound evidence that, in addition to affecting the heart, brain andnervous system, bisphenol A (BPA), could affect a mammal"sability to reproduce by altering the structure of the uterus inways that can progress to a potentially fatal infection. These findings are published in March 9, 2012, advance onlineedition of the Journal of Reproductive Toxicology . Infection and inflammation of the uterus, or pyometra, is mostcommonly seen in animals like dogs and cats but can also affecthumans. It is a result of hormonal and structural changes in theuterus lining and can be deadly if left untreated.
BPA is an industrial chemical and environmental pollutant found inmany hard plastic products. "This condition can be caused by chronic exposure to estrogens;however, it is unknown whether estrogenic endocrine disruptors,like bisphenol A, can cause pyometra," says Scott Belcher,PhD, professor in the department of pharmacology and cellbiophysics and principal investigator on the study. "We wanted tosee if dietary exposures to BPA induced the condition in animalmodels of differing sensitivity to estrogens." Researchers in this study exposed the models to different dietarydoses of BPA in their food, ranging from four to more than 4,000micrograms per kilogram of body weight per day, or17á-ethinyl estradiol (EE), a semi-synthetic steroidal estrogen, in doses of one to greater than150 micrograms per kilogram of body weight per day. A control groupreceived no dose of BPA or EE. "Using two different strains of mouse models, we monitored to seewhich doses of endocrine disruptors affected which strains,"Belcher explains.
"In a commonly used strain of mice, C57BL/6,pyometra occurred with 15 micrograms per kilogram of body weightper day of EE and 33 micrograms per kilogram of body weight per dayof the BPA treatment groups." He continues that at the effective concentration of BPA, immunecell numbers in the uteri of the C57BL/6 strain animals exposedwere increased five-fold compared with control animals. In adifferent strain of mouse (CD1), a similar increase in immune cellnumbers required 100 times greater exposure. "These results suggest that BPA enhances the immune responsivenessof the uterus and that the heightened responsiveness in the C57BL/6strain of females is related to increased susceptibility topyometra," he says. Belcher adds that the reason for this study was to compareappropriate concentrations of dietary estrogenic chemicals to allowreproduction—not to determine whether or not BPA had specificeffects on reproduction or fertility.
"However, in the case where food consumption is altered andreproduction was completely blocked, some interesting and valuableinsight to the impact of these dietary estrogens ispossible," he says. "I t seems likely that the immunologic and structural differencesbetween the strains indicate a potential key difference in susceptibility todeveloping pyometra , which is related to the immune response. We are extremelyinterested in understanding why some strains or individuals areinsensitive to the effects of endocrine disruptors, while othersare resistant to the harmful actions of these chemicals. "The results here suggest that pyometra in the C57BL/6 strain mightserve as a sensitive endpoint for understanding the mechanismsresponsible for the impact of estrogen and estrogenicendocrine-disrupting chemicals on reproduction and also immunity. Further studies using the C57BL/6 strain might serve as auseful model of sensitive subpopulations at risk for developingimmunological disorders related to exposures to estrogen disruptorslike BPA." This study was funded by a grant from the National Institute ofEnvironmental Health Science of the National Institutes of Health. I am a professional writer from Chemical Waste, which contains a great deal of information about vulcan gas range , 6 quart mixers, welcome to visit!
Related Articles -
vulcan gas range, 6 quart mixers,
|
Rate This Article  |
|
|
|
|
|
Do you Agree or Disagree? Have a Comment? POST IT!
| Reader Opinions |
|
|
|
|
|
|
|
|
|
| Author Login |
|
|
 |
Advertiser Login
ADVERTISE HERE NOW!
Limited Time $60 Offer!
90 Days-1.5 Million Views
|
|
TIM FAY
After 60-plus years of living, I am just trying to pass down some of the information that I have lea...more
|
|
|
|
|
LAURA JEEVES
At LeadGenerators, we specialise in content-led Online Marketing Strategies for our clients in the t...more
|
|
|
|
|
ALEX BELSEY
I am the editor of QUAY Magazine, a B2B publication based in the South West of the UK. I am also the...more
|
|
|
|
|
STEPHEN BYE
Stephen Bye is a fiction writer. His most recent novels are a 5-book “The Developer” series which be...more
|
|
|
|
|
PAUL PHILIPS
For more articles, blog messages & videos and a free e-book download go to www.NewParadigm.ws your p...more
|
|
|
|
|
LEVAL AINAH
I am an internet marketer and also an educator. My goal is to help others who are looking to improve...more
|
|
|
|
|
GENE MYERS
Author of four books and two screenplays; frequent magazine contributor. I have four other books "in...more
|
|
|
|
|
ADRIAN JOELE
I have been involved in nutrition and weight management for over 12 years and I like to share my kn...more
|
|
|
|
|
MICHAEL BRESCIANI
Rev Bresciani is the author of two Christian books. One book is an important and concisely written b...more
|
|
|
|
