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Proton pump inhibitors raise fracture risk in older women by wgre ethbtn
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Proton pump inhibitors raise fracture risk in older women |
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Business,Business News,Business Opportunities
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According to an investigation published on bmj.com , hip fractures are 35% more likely to occur in post-menopausal women if they take indigestion medications, known as proton pump inhibitors (PPIs). This figurerises to 50% if the women are former or current smokers. Globally, PPIs are one of the most prevalent drugs used, and areoften used to treat acid reflex and heartburn . However, PPIs can prevent calcium absorption, which leads to theincreased risk of fractures.
From 2000 to 2008, researchers from the Massachusetts GeneralHospital examined the link between hip fractures and PPIs in justunder 80,000 post-menopausal women. According to the researchers, women who smoke and take PPIs for anextended period of time may be up to two times more likely tosuffer from hip fractures than women who do not take PPIs or smoke. In response to the increasing worries regarding long-term PPI useand the risk of hip fractures, numerous investigations have beenconducted, although they have been met with considerablelimitations. The Food and Drug Administration (FDA) issued a warning in May 2010of PPI use and hip fractures, however they concluded that more datawas required for a full examination. The researchers took into account several factors, such as: alcohol intake body weight duration of physical activity smoking status calcium supplement usage menopausal status In addition, the team examined calcium intake from food included ineach participant's diet.
High traumas, such as falling down thestairs or skiing accidents were not included, while low andmoderate traumas associated to fracture, such as falling off achair, or falling on ice were recorded. From 2000 to 2008, results showed that there was a total of 893 hipfractures out of the 79,889 post-menopausal women, concluding thatpost-menopausal women had a 35% increased risk of hip fracture. The researchers found that the risk of hip fracture amongindividuals who regularly use PPIs was 2.02 events per 1,000 personyears (the number of years of follow up multiplied by the number ofparticipants in the study), in comparison with 1.51 events per1,000 person years among women who did not use PPIs. Current andformer smokers were at an even higher risk of 50%. The researchersalso found association between the risk of fractures and theduration of time PPIs were taken.
In 2000, 6.7% of women regularly used a PPI, this figure rose to18.9% in 2008, which poses a greater risk of fractures linked toPPIs in the coming years. Due to this, the FDA plans to reviselabeling on these medications and the researchers underline theimportance of assessing the need for long-term use of PPIs amongindividuals with a history of smoking. The researchers highlightthat two years after patients stopped taking PPIs, their risk ofhip fracture returned to normal. Written by Grace Rattue Copyright: Medical News Today Not to be reproduced without permission of Medical News Today Additional References Citations. I am Electrical Equipment & Supplies writer, reports some information about bosch impact driver , rg6 compression connector.
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