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Testosterone treatment helps obese older males lose weight, otherhealth gains too by wwy yrj





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Testosterone treatment helps obese older males lose weight, otherhealth gains too by
Article Posted: 10/25/2012
Article Views: 60
Articles Written: 1412
Word Count: 514
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Testosterone treatment helps obese older males lose weight, otherhealth gains too


 
Business,Business News,Business Opportunities
Restoring low testosterone levels in older, overweight or obese mento normal levels results in dramatic weight loss and other healthbenefits, such as better blood pressure and blood glucose control,Dr Farid Saad of the Medical Affairs Men's Health Care at BayerPharma AG in Berlin, Germany, explained at the 19th EuropeanCongress on Obesity in Lyon, France. Obesity is linked to lower levels of testosterone, which in turn inducesweight gain. According to earlier research, men aged 45 years orolder with low levels of testosterone are about twice as likely tobe obese and suffer from type 2 diabetes and high blood pressure as compared with age-matched controls. Saad and team decided to examine the impact of normalizing bloodtestosterone levels in predominantly older men with lowtestosterone levels (hypogonadal) in a cumulative, prospectivestudy. They analyzed 251 men between the ages of 38 and 83 years, with anaverage age of 61.



The men's baseline testosterone levels rangedfrom between 0.14 to 3.5 ng/mL, with the cut-off point fortestosterone treatment 3.5. ng/mL (12 nmol/L), a standardcut-off point for testosterone levels to be considered as 'low'.214 men were followed-up for at least 2 years, whilst 115 werefollowed-up for at least 5 years. All participants receivedtestosterone undecanoate 1000 mg, with injections given atbaseline, after 6 weeks and then every 12 weeks throughout thestudy period. Testosterone therapy turned obese men into overweight ones Those followed-up for 5 years lost, on average, 16kg with anaverage weight drop from 106 kg to 90 kg. The average waistcircumference dropped from 107 cm or 42 inches to 98 cm or 38.5inches, whilst the average body-mass index (BMI) dropped from 34 to29, meaning that the men dropped from being classed as 'obese',which is a BMI of over 30 to 'overweight', which is a BMI of 25 to30.



The participants also showed an improvement in other metabolicindicators, such as a drop of LDL or 'bad' cholesterol (mg/dL) from 163 to 109, whilst triglycerides (mg/dL) went downfrom 276 to 189, and the average blood glucose measurements (mg/dL)fell from 103 to 94. In addition, the participants' systolic bloodpressure decreased from 153 to 137 mm Hg and diastolic from 93 to79 mm Hg. According to the researchers, there could be various factorsresponsible for the findings, given that increased testosteronelevels improve energy and motivation to perform physical exerciseand more movement in general. Testosterone also raises lean bodymass, or fat free mass and enhances the patient's energy levels. The researchers also observed no higher risk of prostate cancer in the participants - their risk of the disease did not rise abovethe average for other people of their age and general health.



The authors concluded: "Raising serum testosterone to normal reduced body weight , waist circumference, and blood pressure, and improved metabolicprofiles. These improvements were progressive over the full 5 yearsof the study." Written by Petra Rattue Copyright: Medical News Today Not to be reproduced without permission of Medical News Today Additional References Citations.

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