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Oxygen therapy slows type 1 diabetes in mice, study says by wwy yrj
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Oxygen therapy slows type 1 diabetes in mice, study says by WWY YRJ
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| Article Posted: 11/08/2012 |
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Oxygen therapy slows type 1 diabetes in mice, study says |
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But whether hyperbaric treatment would help humans is unknown. By Serena Gordon HealthDay Reporter FRIDAY, May 11 (HealthDay News) -- Treatment with hyperbaric oxygentherapy helped prevent or slow the progression of type 1 diabetesin mice, according to new research. It is too early to say if the results might apply to humans,however. In mice, the treatment caused changes in the immune system'sresponse to newly developing diabetes, and reduced the risk ofdiabetes between 20 and 40 percent.
In the mice that stilldeveloped diabetes, the hyperbaric therapy delayed diseaseprogression, the investigators found. "Hyperbaric oxygen therapy is a relatively non-harmful way ofenhancing oxygen delivery to the tissues," said the study's seniorauthor, Dr. Antonello Pileggi, director of the preclinical cellprocessing and translational models program at the DiabetesResearch Institute of the University of Miami Miller School ofMedicine. "We were able to suppress the transfer of the disease (in mice)before the onset of the disease. After diabetes had occurred, theefficacy [of hyperbaric therapy] was much less," said Pileggi.
Hesaid that combining hyperbaric therapy with medications mightenhance the effectiveness of both treatments. Results of this study, released online May 7, will be published inthe July print issue of Diabetes . In type 1 diabetes, the immune system mistakenly attacks healthycells in the pancreas called beta cells. Beta cells produce thehormone insulin that allows your body to metabolize carbohydratesfrom food, providing fuel for energy. People with type 1 diabetesmust replace the lost insulin through multiple daily injections ora pump.
Hyperbaric oxygen therapy -- commonly used to treat scuba diverswho develop "the bends" from rising to the surface too quickly --is delivered in a special pressurized chamber. The pressure insidethe chamber is about two and half times greater than the normalpressure in the atmosphere, according to the U.S. National Libraryof Medicine. This puts more oxygen in your blood. Hyperbarictherapy can also be used to treat bone infections, burns, carbonmonoxide poisoning, and wounds that aren't healing well, such asulcers in people with diabetes.
Currently, not very many hospitalsoffer hyperbaric oxygen therapy. For the current research, Pileggi and his colleagues used two typesof mice. One type develops diabetes spontaneously. It's not exactlythe same as type 1 diabetes in humans, but it is very similar, andPileggi said "it's a good surrogate of type 1." And, the secondtype doesn't develop diabetes on its own, but the researchersinduced diabetes. In the mice that spontaneously develop diabetes that receivedhyperbaric therapy, the risk of developing diabetes was reduced by20 percent.
In the mice with induced diabetes, the treatmentreduced the risk of diabetes by 40 percent, according to the study.In the mice that still developed diabetes in both groups, treatmentwith hyperbaric therapy helped delay the onset or progression ofthe disease. Pileggi said that the researchers aren't yet clear exactly how hyperbaric therapy prevents or slows the disease, but it's clearthe therapy has positive effects on the immune system. The researchers were also pleasantly surprised to see that thetherapy caused a significant increase in creation of new betacells. "If you can reeducate immune cells and enhance the beta cellmass, that's an ideal situation. But, it's not a silver bullet fordiabetes.
It could be an adjuvant to other therapies," saidPileggi. Pileggi said the researchers will test combination treatments butadded that it's too soon to guess when such a treatment might betried in humans. Another expert said any application to humans is years away. "This is a novel idea from a good research group. But, while themouse model is good to study, it doesn't mean that what is affectedin mice will be affected in men," said Dr.
Joel Zonszein, directorof the clinical diabetes center at Montefiore Medical Center in NewYork City. Also, it would be difficult to choose who would receive such atherapy, he said, because there isn't a reliable test to determinewho will develop type 1 diabetes. There are tests for theantibodies present in type 1, but some people who never developdiabetes have those same antibodies. "To translate this research to humans would require many moresteps," said Zonszein.
More information Learn more about type 1 diabetes from the American Diabetes Association . SOURCES: Antonello Pileggi, M.D., Ph.D., director, preclinical cellprocessing and translational models program, Diabetes ResearchInstitute, University of Miami Miller School of Medicine; JoelZonszein, M.D., director, clinical diabetes center, MontefioreMedical Center, New York City; May 7, 2012, Diabetes , online Copyright © 2012 HealthDay . All rights reserved. I am Energy Agents writer, reports some information about 3mm round beads , electrical insulators ceramic.
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