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Flu shot during pregnancy shows unexpected benefits in large study - Samsung Instinct Digitizer by e55he swrzsnb





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Flu shot during pregnancy shows unexpected benefits in large study - Samsung Instinct Digitizer by
Article Posted: 12/03/2012
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Articles Written: 2033
Word Count: 499
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Flu shot during pregnancy shows unexpected benefits in large study - Samsung Instinct Digitizer


 
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Researchers at the Ottawa Hospital Research Institute (OHRI), theCHEO Research Institute and the University of Ottawa (uOttawa) useddata from Ontario's birth record database, BORN, to examine 55,570single-child births that took place in Ontario during the H1N1pandemic. The resulting paper was recently published by the American Journal of Public Health. The study shows that, compared to pregnant women who were notimmunized against H1N1, mothers who received the H1N1 vaccinationwere: 34% less likely to have a stillbirth, 28% less likely to deliverbefore 32 weeks, and 19% less likely to give birth to a child witha birth weight for gestational age in the bottom third percentile. "These are all significant results, but especially interestingis the finding that the vaccinated mothers were one-third lesslikely to have a stillborn child," says lead author DeshayneFell, an epidemiologist for BORN Ontario. "This is one of theonly studies large enough to evaluate the association betweenmaternal flu vaccination and stillbirth -- a very rare event." "What surprised me and the research team was the strength ofthe protective benefits we found," says co-author Dr.

AnnSprague, the Scientific Manager of BORN Ontario at the Children'sHospital of Eastern Ontario (CHEO) Research Institute. The study also found no increase in adverse outcomes forH1N1-vaccinated mothers and their babies during the weeks beforeand just after birth, also referred to as the perinatal period. "The findings of this study are very helpful," saysco-author Dr. Mark Walker, a Senior Scientist at OHRI, a High-RiskObstetrician at The Ottawa Hospital, and a Professor and Tier OneResearch Chair in Perinatal Research at the University of Ottawa."Pregnant women are generally very, very careful about whatthey put into their bodies. For health-care providers like me, sucha large-scale study that shows no adverse perinatal outcomesresulting from the H1N1 flu vaccine will be extremely helpful whendiscussing maternal vaccination." Of all the single-child births recorded from November 2009 to April2010, 42% of the women received the H1N1 vaccination, which makesthe findings robust.

BORN -- the Better Outcomes Registry &Network -- collects data from all births in Ontario. In order toconduct the research for this study, questions about H1N1vaccination were added to the database in advance of the H1N1vaccine becoming available. BORN includes demographic data thatallowed the research team to correct for smoking, education andincome; however, as with any population-based study, it may not bepossible to account for all influencing factors. This study was funded by the Canadian Institutes of Health Research(CIHR). The Public Health Agency of Canada provided support to addthe H1N1 questions to the BORN database.

BORN is funded byOntario's Ministry of Health and Long-Term Care, with its mainoffices based at the CHEO Research Institute. Thanks to additional CIHR funding, the researchers are nowfollowing this cohort of children through their first year of lifeto assess possible longer term benefits of the vaccine.

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