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Cholesterol lowering by statins may be affected by gut bacteria - China LED Octopus Downlight by wang dong





Article Author Biography
Cholesterol lowering by statins may be affected by gut bacteria - China LED Octopus Downlight by
Article Posted: 03/19/2013
Article Views: 82
Articles Written: 1102
Word Count: 526
Article Votes: 0
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Cholesterol lowering by statins may be affected by gut bacteria - China LED Octopus Downlight


 
Business,Business News,Business Opportunities
Statins can be effective at lowering cholesterol , but they have a perplexing tendency to work for some people andnot others. Gut bacteria may be the reason. A research team led by a Duke University scientist has identifiedthree bile acids produced by gut bacteria that were evident inpeople who responded well to a common cholesterol-lowering drugcalled simvastatin. The finding, published in PLoS One , demonstrates how gut bacteria can cause inherent differences inthe way people digest, metabolize and benefit from substances suchas drugs.

The study represents the intersection of two emerging researchinterests: An analysis of the intestinal microflora, plus the useof a science called metabolomics, which examines the thousands ofbiochemical components involved in cellular metabolism and how theyaffect health. "This is personalized medicine - the effects of drugs and how werespond," said lead author Rima Kaddurah-Daouk, Ph.D., an associateprofessor in Duke's Department of Psychiatry and leader of thePharmacometabolomics Network. "We found that the benefit of statinscould be partly related to the type of bacteria that lives in ourguts. The reason we respond differently is not only our geneticmakeup, but also our gut microbiome." The researchers gathered data from a subset of participantsenrolled in a large, national project called the Cholesterol andPharmacogenetics (CAP) study, which was led by co-author Ronald M.Krauss, M.D., of Children's Hospital Oakland Research Institute. Inthe smaller gut bacteria trial, Kaddurah-Daouk, Krauss andcolleagues identified 100 people from the CAP study whose LDLcholesterol fell dramatically as a result of taking simvastatin; 24who had a fairly good response on the drug; and 24 who showedlittle benefit.

They then analyzed the blood work from the participants before anyhad taken the drug, searching for known bile acids and fat-likesubstances called sterols that are involved in the body'sbreak-down and use of cholesterol. Among the group who had a strong response to the drug, three bileacids appeared to play a role. The bile acids are produced bycertain gut bacteria, which are increasingly understood asfactories for chemicals that can contribute to a state of health.Among the people who responded poorly to the statin, five differentbile acids were commonly evident. The researchers hypothesize that because bile acids and statinsshare transporter routes to the liver and intestines - they arebasically in competition for a ride - producing more or less ofcertain bile acids could improve or diminish the drug's effects. A blood test that screens for these specific bile acids couldprovide a way for doctors to determine who would respond tosimvastatin and who wouldn't.

Additionally, new strategies could bedeveloped to manipulate the gut microbiome using probiotics to spurdifferent gut bacteria, which could then give the drugs a boost. "We really need to partner with diagnostic and pharmaceuticalcompanies to target drugs for subpopulations," Kaddurah-Daouk said."It's no doubt that metabolites from bacteria are playing animportant role in regulating our systems. We're at a very earlystage of understating this relationship, but eventually we couldtake a quick chemical assay and get a read on where we aremetabolically." Additional References Citations.

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