"We have invented a new optical microscope that can seeindividual blood cells as they flow inside our body," saysLior Golan, a graduate student in the biomedical engineeringdepartment at the Israel Institute of Technology, or Technion, andone of the authors on a paper describing the device that ispublished in the Optical Society's (OSA) open-access journal Biomedical Optics Express . By eliminating a long wait-time for blood test results, the newmicroscope might help spotlight warning signs, like high whiteblood cell count, before a patient develops severe medicalproblems. The portability of the device could also enable doctorsin rural areas without easy access to medical labs to screen largepopulations for common blood disorders, Golan notes. Using the new microscope, the researchers imaged the blood flowingthrough a vessel in the lower lip of a volunteer. They successfullymeasured the average diameter of the red and white blood cells andalso calculated the percent volume of the different cell types, akey measurement for many medical diagnoses. The device relies on a technique called spectrally encoded confocalmicroscopy (SECM), which creates images by splitting a light beaminto its constituent colors. The colors are spread out in a linefrom red to violet. To scan blood cells in motion, a probe ispressed against the skin of a patient and the rainbow-like line oflight is directed across a blood vessel near the surface of theskin. As blood cells cross the line they scatter light, which iscollected and analyzed. The color of the scattered light carriesspatial information, and computer programs interpret the signalover time to create 2-D images of the blood cells. Currently, other blood-scanning systems with cellular resolution doexist, but they are far less practical, relying on bulky equipmentor potentially harmful fluorescent dyes that must be injected intothe bloodstream. "An important feature of the technique is its reliance onreflected light from the flowing cells to form their images, thusavoiding the use of fluorescent dyes that could be toxic,"Golan says. "Since the blood cells are in constant motion,their appearance is distinctively different from the static tissuesurrounding them." The team's technique also takes advantageof the one-way flow of cells to create a compact probe that canquickly image large numbers of cells while remaining stationaryagainst the skin. At first, the narrow field of view of the microscope made itdifficult for the team to locate suitable capillary vessels toimage. To solve this, the researchers added a green LED and camerato the system to provide a wider view in which the blood vesselsappeared dark because hemoglobin absorbs green light."Unfortunately, the green channel does not help in finding thedepth of the blood vessel," notes Golan. "Adjusting theimaging depth of the probe for imaging a small capillary is still achallenge we will address in future research." The researchers are also working on a second generation system withhigher penetration depth. The new system might expand the range ofpossible imaging sites beyond the inside lip, which was selected asa test site since it was rich in blood vessels, has no pigment toblock light, and doesn't lose blood flow in trauma patients. Additional steps include work to miniaturize the system for ease oftransport and use. "Currently, the probe is a bench-toplaboratory version about the size of a small shoebox," saysGolan. "We hope to have a thumb-size prototype within the nextyear.". I am an expert from lipolaser-machines.com, while we provides the quality product, such as Cryolipolysis Machine , China Laser Tattoo Removal Machine, Diode Hair Removal Laser,and more.
Related Articles -
Cryolipolysis Machine, China Laser Tattoo Removal Machine,
|