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In a new study, scientists have found novel mutations to beassociated with chronic pancreatitis (inflammation of pancreas),reinforcing earlier observations that genetic susceptibility forthe disease was different in Indians as compared to Americans andEuropeans. The study was conducted by the Centre for Cellular and MolecularBiology in collaboration with Asian Healthcare Foundation, AsianInstitute of Gastroenterology, Department of Gastroenterology, SCBMedical College, Cuttack and Department of Gastroenterology,Medical College, Calicut. According to Dr.Giriraj Ratan Chandak, lead author of the study,which was published in GUT online on May 12, the team at CCMB had been investigating chronicpancreatitis for more than 10 years and established earlier thatthe genetic basis for it was different among Indians. It was foundthat unlike in Americans and Europeans, mutations in trypsinogen, agut enzyme, which digests the pancreas and causes pancreatitis, wasnot doing so in Indians. Rather, mutations in an inhibitor or Cathepsin B (CTSB) whichcontrol the activation of pancreas, were found to be responsiblefor the condition among Indians. In the latest study, a comprehensive analysis of chymotrypsin C(CTRC) gene was undertaken in 584 patients after genomic DNA wasisolated from all the individuals. A cohort of 598 ethnically matched individuals who had nocomplaints or evidence of pancreatitis were recruited as controls. The scientists found seven novel mutations and observed thatsubjects with the variants were at a higher risk for chronicpancreatitis. Dr. Chandak said the study revealed that the mutational spectrum ofthe disease in India was different from Europe and America. Whilethere was no definite epidemiological data, it was estimated thatchronic pancreatitis affects one in every 1600 people in thecountry. The clinical picture of the disease too was different as it getspresented five to 10 years earlier among Indians as compared tothose in the Western countries. Similar was the case with diabetes, abdominal obesity, high bloodpressure and cataract, all of which get manifested five to tenyears earlier in Indians than in other groups. He said the study brought out two important issues — that thegenetic basis of diseases in Indians was different and needed to beinvestigated rather than extrapolating results from internationalstudies. Secondly, identification of these mutations would help insusceptibility screening and help develop therapeutic regimens orunique drug targets for Indians. We are high quality suppliers, our products such as China Mens Stainless Steel Bracelets , Huggie Earring Manufacturer for oversee buyer. To know more, please visits Womens Stainless Steel Bracelets.
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