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Researchers discover tactic to delay age-related disorders by 123wert sdfsf
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Researchers discover tactic to delay age-related disorders |
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Business,Business News,Business Opportunities
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Researchers at Mayo Clinic have shown that eliminating cells thataccumulate with age could prevent or delay the onset of age-relateddisorders and disabilities. The study, performed in mouse models,provides the first evidence that these "deadbeat" cells couldcontribute to aging and suggests a way to help people stayhealthier as they age. The findings appear in the journal Nature,along with an independent commentary on the discovery. "By attacking these cells and what they produce, one day we may beable to break the link between aging mechanisms and predispositionto diseases like heart disease , stroke , cancers and dementia ," says co-author James Kirkland, M.D., Ph.D., head of Mayo'sRobert and Arlene Kogod Center on Aging and the Noaber FoundationProfessor of Aging Research.
"There is potential for a fundamentalchange in the way we provide treatment for chronic diseases inolder people." Five decades ago, scientists discovered that cells undergo alimited number of divisions before they stop dividing. At thatpoint the cells reach a state of limbo -- called cellularsenescence -- where they neither die nor continue to multiply. Theyproduce factors that damage adjacent cells and cause tissueinflammation. This alternative cell fate is believed to be amechanism to prevent runaway cell growth and the spread of cancer.The immune system sweeps out these dysfunctional cells on a regularbasis, but over time becomes less effective at "keeping house." As a result, senescent cells accumulate with age.
Whether and howthese cells cause age-related diseases and dysfunction has been amajor open question in the field of aging. One reason the questionhas been so difficult to answer is that the numbers of senescentcells are quite limited and comprise at most only 10 to 15 percentof cells in an elderly individual. "Our discovery demonstrates that in our body cells are accumulatingthat cause these age-related disorders and discomforts," sayssenior author Jan van Deursen, Ph.D., a Mayo Clinic molecularbiologist and the Vita Valley Professor of Cellular Senescence."Therapeutic interventions to get rid of senescent cells or blocktheir effects may represent an avenue to make us feel more vital,healthier, and allow us to stay independent for a much longertime." "Through their novel methodology, the research team found thatdeletion of senescent cells in genetically engineered mice led toimprovement in at least some aspects of the physiology of theseanimals. So, with the caveat that the study involved a mouse modeldisplaying accelerated aging, this paper provides importantinsights on aging at the cellular level," says Felipe Sierra,Ph.D., Director of the Division of Aging Biology, NationalInstitute on Aging, National Institutes of Health. How They Did It Dr.
van Deursen and colleagues genetically engineered mice so theirsenescent cells harbored a molecule called caspase 8 that was onlyturned on in the presence of a drug that has no effect on normalcells. When the transgenic mice were exposed to this drug, caspase8 was activated in the senescent cells, drilling holes in the cellmembrane to specifically kill the senescent cells. The researchers found that lifelong elimination of senescent cellsdelayed the onset of age-related disorders such as cataracts and muscle loss and weakness. Perhaps even more importantly, theyshowed that removing these cells later in life could slow theprogression of already established age-related disorders. The findings support a role of senescent cells in the aging processand indicate that chemicals secreted by these cells contribute toage-related tissue dysfunction and disease.
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