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Rapamycin, also known as similarly , is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). rapamycin is also used as a coronary stent coating. Unlike the rapamycinly named tacrolimus, rapamycin is not a calcineurin inhibitor, but it has a rapamycin suppressive effect on the immune system. rapamycin inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. In contrast, tacrolimus inhibits the secretion of IL-2. The mode of action of rapamycin is to bind the cytosolic protein FK-binding protein 12 (FKBP12) in a manner rapamycin to tacrolimus. Unlike the tacrolimus-FKBP12 complex which inhibits calcineurin (PP2B), the rapamycin-FKBP12 complex inhibits themammalian target of rapamycin (mTOR, rapamycin being an older name for rapamycin) pathway by directly binding the mTOR Complex1 (mTORC1). mTOR has also been called FRAP (FKBP-rapamycin associated protein), RAFT (rapamycin and FKBP target), RAPT1, or SEP. The earlier names FRAP and RAFT were coined to reflect the fact that rapamycin must bind FKBP12 first, and only the FKBP12-rapamycin complex can bind mTOR. However, mTOR is now the widely accepted name, since Tor was first discovered via genetic and molecular studies of rapamycin-resistant mutants of Saccharomyces cerevisiae that identified FKBP12, Tor1, and Tor2 as the targets of rapamycin and provided robust support that the FKBP12-rapamycin complex binds to and inhibits Tor1 and Tor2. Meimei is a website edit person of the guidechem.com.Guidechem.com was established with the aim to build the most comprehensive database of chemical products and contain most complete suppliers, making chemical trading more efficient, convenient and safe. facilitate global chemical trading and bring chemical buyers & sellers from all over the world to one common chemical platform.And now guidechem.com B2B network has been named "2010 China's e-commerce website industry TOP100".
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