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Naringin is the chemical compound in grapefruit that is responsible for its bitter taste. It is classified as a phytochemical, which is a naturally occurring plant compound with potential nutritional benefits. Specifically, naringin is a water soluble flavonoid. It has been studied for its potential antioxidant and anti-carcinogenic properties, as well as its effects on enzyme activity in the digestive tract. Supplements containing naringin are typically used to enhance the effects of other drugs. 1.How does it work? Naringin is a flavonoid found in grapefruits, and gives grapefruit its characteristic bitter flavor. Grapefruit processors attempt to select fruits with a low naringin content, and often blend juices obtained from different grapefruit varieties to obtain the desired degree of bitterness. Naringin is believed to enhance our perception of taste by stimulating the taste buds (some people consume a small amount of grapefruit juice before a meal for this reason). On its own, Naringin has very little benefit. However, studies shown that naringin interferes with enzymatic activity in the intestines and, thus, with the breakdown of certain nutrients resulting in higher blood levels [1, 2]. Approximately 25 milligrams of Naringin is needed to enhance both the bioavailability and half-life of nutrients consumed with it. 2.What can it be combined with? Naringin enhances both the oral uptake and half-life in the body of nutrients such as Forskolin or Guggulsterones. Approximately 20-25 milligrams of Naringin is needed to produce this effect. 3.What effect dose it have? A variety of other pharmacological effects have been observed in vitro or in animal studies, but their relevance to human health in unknown. These effects include: *Naringin is an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis. *Naringin reduced diabetes-induced neuropathy in rats. *Naringin has shown protective effects on cognition and oxidative damage in rats.
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