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Cyromazine is a kind of triazine insect growth regulator and a systemic insecticide that is highly effective against leaf miners and fly larvae. It comes under the s-triazine class of chemicals with several herbicidal compounds. The only difference is that unlike any other compounds of the triazine class, it does not have any herbicidal activity. The correct mechanism of action for this drug is still not known. It has been however contended that it functions through the hormone that controls ecdysis including the deposit of cuticle in insects. It is a cyclopropyl derivative of melamine. The active agent in the formulation, Larvadex 2SL is Cyromazine. This formulation is presently put forward for registration in California. This formulation is allowed only for direct application on chicken manure as a fly larvacide. The Larvadex 2SL including other Cyromazine formulations have been registered for usage in various other states of the United States Environmental Protection Agency (U.S. EPA). The drug is available for sheep as concentrates for the purpose of spraying and dipping and also as pour-on por blowfly strike prevention. This drug is also used as a feed additive for poultry for controlling houseflies in the manure as well as concentrate for manure along with environmental treatment against various houseflies and any other type of flies. Earlier, there existed only a few products for on and off-animal flea control on dogs. They have all been with-drawn. PHARMACOLOGY OF CYROMAZINE Topically administered Cyromazine is badly ingested through the skin. This drug is quite dissolvable in water as against several other types of ectoparasiticides which are lipophilic. On completing oral administration to poultry, about 99 percent of the allotted dose is excreted in an unchanged fashion in the feces. A small amount of about 0.6 percent gets deposited in the eggs and a few others in the chicken tissues. Most of the ingested Cyromazine in poultry and mammals are absorbed into blood. A little of it is metabolized in the liver and the major portion is excreted out via urine. The process of excretion is quite fast. Approximately 95 percent of the absorbed dose is excreted out within a span of 24 hours after administration. In case of treated poultry, as the drug excreted out through urine is combined with the feces in the cloaca, the manure is treated in a uniform manner that lets for a better control of the fly maggots. In case of mammals, the ingested drug does not however end in the feces. It ends in the urine and as a consequence it cannot be utilized for manure fly control as a feed-through larvicide. MECHANISM OF ACTION OF CYROMAZINE The mechanism of action of this drug is definitely not like the Chitin Synthesis Inhibitor of other development inhibitors such as benzoylureas. It nonetheless works upon the molting procedure. It might interfere with the procedure of chitin deposition as well. For comprehensive information on the drug, one can also browse the internet or can get in touch with a veterinary doctor or a knowledge expert professional.
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