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Insulin replacement therapy will continue to dominate the market in the next 10 years by Ma tracy
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Insulin replacement therapy will continue to dominate the market in the next 10 years by MA TRACY
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| Article Posted: 01/15/2012 |
| Article Views: 85 |
| Articles Written: 1018 - MORE ARTICLES FROM THIS AUTHOR |
| Word Count: 585 |
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Insulin replacement therapy will continue to dominate the market in the next 10 years |
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Business,Marketing,Health
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Juvenile or insulin-dependent diabetes is an autoimmune and metabolic diseases characterized by T cells leading to pancreatic ß-cell damage resveratrol and thereby causing insulin secretion and high blood sugar. In 2007, there are 437,500 children with insulin-dependent diabetes mellitus in the world. It increases 70,000 children under the age of 14 with insulin-dependent diabetes mellitus every year. The annual growth rate is 3%, especially for the younger children. Current insulin replacement therapy is to save the life of the first-line treatment of diabetes drugs, the pharmaceutical industry, traditionally the focus of attention is the development of more convenient to use, by other means of innovative insulin delivery. It is understood that the world's seven major pharmaceutical markets has been diagnosed and treated about 184 patients with insulin-dependent diabetic people with type 1 diabetes drug market reached 20 billion U.S. dollars. Although insulin replacement therapy could save the lives of patients, but not cure the disease, and even lead to low blood sugar, but does not prevent complications. Therefore, the development of drugs to alter the disease process is imminent. Currently, the most advanced treatment strategies, through the induction of immune tolerance or regulation of autoimmune and inflammatory response, delaying the process of insulin-dependent diabetes mellitus. The new vaccine is under development, including glutamic acid decarboxylase GAD65 and BHT-3021. Non-antigen-specific immunomodulatory agents, such as CD3 monoclonal antibody Otelixizumab and Teplizumab also under development. As the mechanism of the reason, these drugs may harm the normal immune system function. In addition, many have been FDA-approved immunomodulatory agents are in clinical trials. While the vaccine can delay or prevent further decline in ß-cell function, but once the patient was diagnosed with insulin-dependent diabetes, and its only 10% to 20% of the ß-cell function was normal. Therefore, vaccines based on tolerance pathways for those with type 1 diabetes onset in high-risk patients the most effective. However, this treatment the incidence of those who have already lost most of ß-cell function in patients, results to be worse. Early onset of insulin-dependent diabetes mellitus, diabetes in the transformation to occur before clinical symptoms, non-antigen-specific immunomodulatory agents for patients with the most effective. Overall, non-antigen-specific therapy based on the safety or benefit from this treatment of the population is limited, and therefore such immunity for the treatment of diabetes drug market is limited. Has found that certain peptides and growth factors such as gastrin, glucagon-like peptide growth factors (GLP1) of ß cell mass to expand, so that due to the lack of immunosuppressive agents, animal models of insulin-dependent diabetes mellitus blood sugar returned to normal. FDA has approved two drugs dipeptidyl peptidase 4 (DPP4) inhibitors and proton pump inhibitors, can increase non-obese diabetic (NOD) mouse circulatory system in GLP1 and gastrin levels, which for these channels tested in humans provides a theoretical basis. Any kind of regenerative therapy may be uncontrolled hindered by its own immune response chia seed, therefore, the safety, tolerability antigen-specific therapies and emerging applications of regenerative therapy combined with drug development will be the next step. From the view of current R & D treatment of insulin-dependent diabetes, in the next 10 years, insulin replacement therapy will continue to dominate the market. In the long terms, the regenerative medicine of tolerance drugs, ß-cell antigen-specific and specific diseases in the early development will provide a very promising platform for development of disease modifying drugs. Although single drug of these drugs will go to the market earlier, combination therapy is the most effective way for insulin -dependent diabetes. Source:http://www.cospcn.com
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