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Super-sticky 'ultra-bad' cholesterol revealed in people at highrisk of heart disease by efwegbe erergeer
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Super-sticky 'ultra-bad' cholesterol revealed in people at highrisk of heart disease |
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Business,Business News,Business Opportunities
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Scientists from the University of Warwick have discovered why anewly found form of cholesterol seems to be 'ultra-bad', leading to increased risk of heart disease . The discovery could lead to new treatments to prevent heartdisease particularly in people with type 2 diabetes and the elderly. The research, funded by the British Heart Foundation (BHF), foundthat 'ultrabad' cholesterol, called MGmin-low-density lipoprotein(LDL), which is more common in people with type 2 diabetes and theelderly, appears to be 'stickier' than normal LDL. This makes itmore likely to attach to the walls of arteries. When LDL attachesto artery walls it helps form the dangerous 'fatty' plaques' thatcause coronary heart disease (CHD).
CHD is the condition behind heart attacks , claiming 88,000 lives in the UK every year (1). The researchers made the discovery by creating human MGmin-LDL inthe laboratory, then studying its characteristics and interactionswith other important molecules in the body. They found that MGmin-LDL is created by the addition of sugargroups to 'normal' LDL - a process called glycation - making LDLsmaller and denser. By changing its shape, the sugar groups exposenew regions on the surface of the LDL.
These exposed regions aremore likely to stick to artery walls, helping to build fattyplaques. As fatty plaques grow they narrow arteries - reducingblood flow - and they can eventually rupture, triggering a bloodclot that causes a heart attack or stroke . The discovery might also explain why metformin, a widely prescribedtype 2 diabetes drug, seems to lead to reduced heart disease risk.Metformin is known to lower blood sugar levels, and this newresearch shows it may reduce the risk of CHD by blocking thetransformation of normal LDL to the more 'sticky' MGmin-LDL. Dr Naila Rabbani, Associate Professor of Experimental SystemsBiology at Warwick Medical School, who led the study, said: "We're excited to see our research leading to a greaterunderstanding of this type of cholesterol, which seems tocontribute to heart disease in diabetics and elderly people. Type 2diabetes is a big issue - of the 2.6 million diabetics in the UK,around 90 per cent have type 2.
It's also particularly common inlower income groups and South Asian communities. (2, 3) "The next challenge is to tackle this more dangerous type ofcholesterol with treatments that could help neutralise its harmfuleffects on patients' arteries." Dr Shannon Amoils, Research Advisor at the BHF, which funded thestudy, said: "We've known for a long time that people with diabetes are atgreater risk of heart attack and stroke. There is still more workto be done to untangle why this is the case, but this study is animportant step in the right direction. "This study shows how the make-up and the shape of a type of LDLcholesterol found in diabetics could make it more harmful thanother types of LDL. The findings provide one possible explanationfor the increased risk of coronary heart disease in people withdiabetes.
"Understanding exactly how 'ultrabad' LDL damages arteries iscrucial, as this knowledge could help develop new anti-cholesteroltreatments for patients." The research was published in the journal Diabetes . Notes: 1. Scarborough P et al (2010). Coronary heart disease statistics2010 edition. British Heart Foundation: London.
2 Diabetes UK (2010). Diabetes in the UK: Key statistics ondiabetes online. 3. Department of Health (2007). About diabetes online.
4. Research published in Diabetes online 27/05/11: 'Glycation of low density lipoprotein bymethylglyoxal increases atherogenicity - a possible contributor toincreased risk of cardiovascular disease in diabetes'. DOI10.2337/db11-0085 Source: Kate Cox University of Warwick Additional References Citations. I am a professional writer from Other Agriculture Products, which contains a great deal of information about metal garbage cans , outside wall lighting, welcome to visit!
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