hormonal contraception: low estrogen and progestogen component, compared with COCs lower risk of cardiovascular diseases and cerebrovascular disorders, have no effect on carbohydrate metabolism and blood clotting system; exert a therapeutic effect in dysmenorrhea, PMS, ovulatory pain, inflammatory diseases of the internal genital organs; rapid restoration of fertility (for 3 months after stoping the drug use); it is allowed to be used during lactation; may be used by smoking women over 35 years old; it is ease to use. More information about pharmatex, combined oral contraception, combined contraception, spermicides, prevent pregnancy, hormonal contraception on www.contraceptionlist.com">Oral contraceptives mini-pill contain only small doses of progestogen (300-500 g), which is 15-30% of the dose of progestogen in combined estrogen-progestin preparations. The action mechanism of contraceptive mini-pill result the following factors: cervical factor - under the influence of minipill decreases the amount of cervical mucus ( increases its viscosity), which reduces the penetrating ability of sperm in ovulatory period; uterine factor - the use of mini pills leads to changes in the endometrium, preventing implantation (premature secretory transformation, in long-term use - endometrial atrophy); tubal factor - mini pills cause slower migration of the egg through the fallopian tube, due to a decreasement of contractile activity of the fallopian tubes; central factor - in 25-30% of patients mini pills suppress ovulation. Contraceptive efficacy of mini pills - 0,3-9,6 pregnancies per 100 women / years. Minipill - only reliable method of contraception in lactating women. In other situations, it should be employed only if it is impossible to use a more robust methods such as COC. Mini pills are taken continuously every day, at the same time of day from the 1st day of the menstrual cycle. As in most cases ovulation in women persists, reliable contraception can be achieved only with careful adherence of mini pill (deviation in the time of reception of no more than 3 hours). Indications for admission: lactation (after 6 weeks postpartum) - mini pills don't affect the duration of lactation, the quantity and quality of milk, the presence of contraindications to estrogen (number of extragenital diseases), or a history of estrogen-dependent complications, reproductive age, including late, premenopausal , obesity. Mini pill contraindications are the same as in COCs. Side effects of mini pill: menstrual irregularities, nausea, vomiting, depression, weight gain, decreased libido, headache, dizziness, breast engorgement. Limitations of the method: lower contraceptive efficacy compared with the COC; need for strict adherence to the regimen of the drug (strictly in the same time), increasing risk of developing functional ovarian cysts, and increasing risk of ectopic pregnancy (its frequency is 2 per 100 women / years, however, in accordance with the eligibility criteria of WHO ectopic pregnancy in history class assigned to 2nd of admissibility, that the benefits of using the method exceeds the theoretical and proven risk); menstrual disorders: ? appearance of acyclic uterine bleeding; ? shortening of the menstrual cycle to near 25 days or less; ? occurrence of uterine bleeding "breakthrough." Advantages of the mini pill hormonal contraception: low estrogen and progestogen component, compared with COCs lower risk of cardiovascular diseases and cerebrovascular disorders, have no effect on carbohydrate metabolism and blood clotting system; exert a therapeutic effect in dysmenorrhea, PMS, ovulatory pain, inflammatory diseases of the internal genital organs; rapid restoration of fertility (for 3 months after stoping the drug use); it is allowed to be used during lactation; may be used by smoking women over 35 years old; it is ease to use. More information about pharmatex, combined oral contraception, combined contraception, spermicides, prevent pregnancy, hormonal contraception on www.contraceptionlist.com
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