Weight loss improved both metabolic parameters and sleep-disorderedbreathing (SDB) in obese children in a new study from researchersin Belgium, confirming links between metabolic dysregulation, SDBand obesity . "SDB is highly prevalent in childhood obesity, and may be a riskfactor for the metabolic syndrome. In our population of 224 obesechildren and adolescents, 30% had SDB, which was significantlycorrelated with metabolic parameters, including aspartateaminotransferase (ASAT), alanine aminotransferase (ALAT) and HDL cholesterol at baseline," said Stijn Verhulst, MD, MSc, PhD, coordinator ofthe pediatric sleep lab at the Antwerp University Hospital,Belgium. "After weight loss, all metabolic parameters improved, andjust 24% of the study group had residual SDB." The results were presented at the ATS 2012 International Conferencein San Francisco. Median age of the children in the study was 15.5 years (range10.1-18.0). Participants underwent baseline sleep screening andthose with diagnosed SDB underwent additional sleep screeningfour-six months after weight loss treatment. A fasting blood assaywas performed at baseline and at four-six months. Mean BMI at baseline was 36.4 kg/m2. After a six-month weight lossprogram that incorporated diet, increased physical activity andpsychological support, mean BMI was reduced to 29.2 kg/m2. ASATimproved after weight loss in parallel with an improvement inoxygen saturation during sleep, while HDL-cholesterol mainlyimproved with lowering BMI. "The association between SDB and metabolic parameters in childrenremains controversial," said Dr. Verhulst. "This study confirmedthe independent effect of nocturnal hypoxia on HDL-cholesterol andliver enzyme levels in morbidly obese teenagers with SDB atbaseline. We also confirmed that weight loss has a high successpercentage in the treatment of SDB in obese teenagers. Furthermore,both weight loss and the consequent improvement in SDB both driveimprovements in metabolic dysregulation." "Because of the high dropout rate after six months and therelatively limited number of subjects with residual sleep apnea,these findings need to be confirmed in a larger study," Dr.Verhulst concluded. "Furthermore, it remains important to study themechanisms linking SDB with these metabolic parameters in obeseteens and to study the long-term effects of SDB on future metabolicand cardiovascular morbidity." Additional References Citations. The e-commerce company in China offers quality products such as China T8 LED Tubes , China Brightest LED Light, and more. For more , please visit LED Globe Lights today!
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