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| Articles by Calder Qimat |
71. Quantitative structure-activity relationship
January 02, 2012
Introduction
High throughput screening technology has been improved by the assistance of numerous other technologies including the combinatorial and computational approaches. QSAR is one of the computational tools which facilitate the process of hit to lead generation in HTS. Quantitative st...
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72. REGORAFENIB - INHIBITS KINASES INVOLVED IN THE PROCESS OF ANGIOGENESIS
December 22, 2011
A tumor needs a continuous blood supply for its growth beyond 1-2mm in dimension. The process of angiogenesis is related with the development of new blood vessels from the older ones and this process maintains a constant supply of oxygen to the growing tumor. The members belonging to the VEGF family...
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73. FLT3 inhibitor Quizartinib plays an important role in treating Acute Myeloid Leukemia
December 22, 2011
INTRODUCTION
Acute myeloid leukemia (AML) is a neoplasm of the myeloid blood cells, which is characterized by unrestrained growth of white blood cells. The abnormal cells accumulate in the bone marrow where they interfere with the production of normal blood cells. AML is a relatively rare ma...
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74. New tyrosine kinase inhibitor shows unprecedented promise for treatment of colorectal cancer
December 22, 2011
INTRODUCTION
Colorectal cancer is a malignancy of unrestrained cell growth in the colon, rectum, or appendix. Colon cancer affects approximately 1 million people per year and is the third most common cancer worldwide, however it is more common in developed countries due to lifestyle risk fac...
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75. Neratinib in new breast cancer biomarker study
December 22, 2011
INTRODUCTION
In recent years, breast cancer awareness has grown considerably but the disease itself remains deadly and is the second leading cause of cancer related deaths among women in the US. Approximately 30% of breast cancer diagnoses, particularly the more aggressive cases, are charact...
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76. Biophysical Assay Methods in HTS
December 22, 2011
Introduction
The key strategy of drug development in the contemporary era involves the screening of compound libraries. The process of HTS becomes useful only when the results of screening analysis are visualized. This visualization is accomplished by performing high quality HTS assays which...
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77. EGF Receptor for HTS
December 20, 2011
Introduction
High throughput screening is a wonder tool to identify the targets like needles in the haystack. This technique has been able to provide screening libraries which inhibit a wide range of targets having a heady role in a variety of leukemias. The inhibitors provided in compound l...
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78. Technologies have been developed to cast designs of hits
December 20, 2011
Introduction
High throughput screening technology has played a key role in the development of inhibitors against particular targets via in vitro assays. However every inhibitor cannot be used directly as a drug. It has to undergo a series of examinations and optimizations before use in livin...
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79. SP600125 - NEW JNK INHIBITOR
December 20, 2011
INTRODUCTION ERK, JNK and p38 MAPK are vital and central elements of the MAPK family. They help in the transmission of those signals which originate due to stress, cytokines or growth factors. ERK is the final enzyme of the MAPK pathway which transmits signals into the nucleus. The ultimate ...
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80. TIPIFARNIB AND FTP ENZYME
December 19, 2011
INTRODUCTION
Cancers show large scale of heterogenicity and account for a huge death toll. A normal functioning of different signaling pathways is very essential for the proper functioning of the cells. Amongst these pathways, the Ras activated MAPK pathway, is very important and its hyperac...
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Author: Calder Qimat
