|
|
 |
|
| Articles by Calder Qimat |
91. B-RAF INHIBITORS IS A TREATMENT FOR CANCER
December 15, 2011
IMPLICATIONS OF B-RAF OVER-ACTIVATION:
B-Raf pathway is implicated in cellular processes like cell growth, survival and sustained proliferation of the cells. The Raf/MEK/ERK pathway has been known to be contributing to the aforementioned signaling cascades [1]. Since the over-activation of t...
|
|
 |
92. ANGIOGENESIS INHIBITORS TACKLING VASCULARIZATION
December 15, 2011
THERAPIES AGAINST ANGIOGENESIS:
The physiological process of vascularization involving growing new blood vessels from the pre-existing ones is popularly known as angiogenesis. In growth, development, wound healing etc. angiogenesis is very important and required to support the vasculature of...
|
|
|
93. XL880 INHIBITOR
December 15, 2011
IMPLICATION OF VEGF-R/KDR/MET INHIBITION IN CANCERS AND XL880:
Many cancers harbor overexpressed Met receptor tyrosine kinase (MTK), its ligand hepatocyte growth factor (HGF) and its interacting protein vascular endothelial growth factor (VEGF) receptors (VEGF-Rs) like Kinase insert domain r...
|
|
|
94. TOSEDOSTAT: INHIBITING AMINOPEPTIDASES IN CANCERS
December 15, 2011
AMINOPEPTIDASES AND THEIR INHIBITION:
Aminopeptidases are zinc dependent enzymes that are made and released by the glands of the small intestine. These proteins catalyze the hydrolysis of various amino acids from the -NH2 terminal of proteins and hence the use of inhibitors which would block...
|
|
|
95. AV-951 IN THE TREATMENT OF ANGIOGENIC
December 15, 2011
ANGIOGENESIS AND AV-951:
Angiogenesis as a process is very crucial for the progression of tumors. Not only cells proliferate uncontrollably in cancers, they require a better vascular system to support these new and upcoming cells. Hence the development of anti-angiogenesis compounds is seen ...
|
|
|
96. AZD2281IS A NEW INHIBITOR
December 14, 2011
Compound Libraries, compound library, High Throughput Screening, Screening Libraries, |
|
97. BMS-777607 - A POTENT ANTI-CANCER MOLECULE FOR PROSTATE CANCER
November 30, 2011
INTRODUCTION:
The dysregulation of activity of cellular c-Met is one of the common events that happen in cancers. This phenomenon is powerfully implicative in the distant metastasis of various tumors and cancers. In case of prostate cancers, the enhanced MET expression by means of the transc...
|
|
|
98. SORAFENIB - MOLECULAR MECHANISMS AND ACTIONS
November 30, 2011
INTRODUCTION:
Liver cancer or the hepatocellular carcinoma (HCC) is considered the fifth most common deadly cancer throughout the world. According to an estimate, the annual death rate due to this cancer is up to 60, 000 [1]. The angiogenesis and signaling through the extracellular signal-re...
|
|
|
99. LY2228820 - Molecular Functions and Advantages
November 30, 2011
INTRODUCTION:
P38 MAPK when activated causes the enhanced production of cytokines by inhibiting the degradation of their messenger RNA. On the contrary, if the p38 MAPK inhibition is suppressed, the cytokine production is also inhibited. These are the cytokines which may produce the osteocla...
|
|
|
100. VX-702 - A Great Molecule for Rheumatoid Arthritis and Acute Coronary Syndrome
November 30, 2011
INTRODUCTION: The researchers are taking great interest in selecting the intracellular inhibitors of p38 MAPK in order to treat the Rheumatoid Arthritis. There are many inhibitors which have been formed and researched in various clinical studies related to the chronic inflammatory diseases. VX-702...
|
|
|
|
|
|
>
|
|
|
|
|
| Author Login |
|
|
 |
Advertiser Login
ADVERTISE HERE NOW!
Limited Time $60 Offer!
90 Days-1.5 Million Views
|
|
GENE MYERS
Author of four books and two screenplays; frequent magazine contributor. I have four other books "in...more
|
|
|
|
|
TIM FAY
After 60-plus years of living, I am just trying to pass down some of the information that I have lea...more
|
|
|
|
|
LAURA JEEVES
At LeadGenerators, we specialise in content-led Online Marketing Strategies for our clients in the t...more
|
|
|
|
|
ALEX BELSEY
I am the editor of QUAY Magazine, a B2B publication based in the South West of the UK. I am also the...more
|
|
|
|
|
SUSAN FRIESEN
Located in the lower mainland of B.C., Susan Friesen is a visionary brand strategist, entrepreneur, ...more
|
|
|
|
|
STEPHEN BYE
Steve Bye is currently a fiction writer, who published his first novel, ‘Looking Forward Through the...more
|
|
|
|
|
SHALINI MITTAL
A postgraduate in Fashion Technology. Shalini is a writer at heart! Writing for her is an expression...more
|
|
|
|
|
ADRIAN JOELE
I have been involved in nutrition and weight management for over 12 years and I like to share my kn...more
|
|
|
|
|
JAMES KENNY
James is a Research Enthusiast that focuses on the understanding of how things work and can be impro...more
|
|
|
|
Author: Calder Qimat
