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| Articles by kate edson |
71. SB939 - ARRESTS THE PRLIFERATION OF CANCEROUS CELLS, Panobinostat, Vorinostat
January 17, 2012
The enzymes which add acetyl group on the histones are called HAT enzymes. These enzymes are involved in the stimulation of certain transcription factors to enhance the genetic expression of specific genes. Hence these enzymes are involved in the transcription of certain genes. On the other hands th...
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72. LY294002 indicates that GH has direct stimulatory actions on chondrocyte proliferation
January 17, 2012
Most bones from fetus, such as the limbs, trunk, bone and skull base, are mainly developed in the way of endochondral bone. This kind of bone development contains not only the process similar with the development of intramembranous ossification , but also the continued growth and degradation of cart...
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73. The Molecular Mechanisms of Sorafenib and Vorinostat
January 16, 2012
The present studies attempted to determine, in much greater detail, the molecular mechanisms by which sorafenib and vorinostat, as individual agents, interacted to activate CD95 and promote drug toxicity.Sorafenib caused a dose-dependent increase in CD95 tyrosine phosphorylation and, based on multip...
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74. MEDIATING ALK INHIBITION IN TUMORS SB-431542
January 16, 2012
Activin receptor like-kinases (ALK1) are defined as being a type 1 receptor specifically for the transforming growth factor ß (TGF-ß) family of proteins. It is recorded that ALK1 expression is found in blood vessels and may be linked to vascular formation. Since tumor growth is dependant on generati...
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75. Olaparib and INCB018424 :two good inhibitors-PARP inhibitor,Olaparib,INCB018424
January 16, 2012
Bortezomib, Velcade, Dasatinib & more. We have headquarters in both United States and Europe, and also has 38 distributors worldwide. We provide overnight delivery ...
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76. PARP and ALK inhibitors
December 30, 2011
ABT-888 shows a preferential activity on those MSI cell lines harboring mutations in both MRE11 and RAD50 genes compared to MSS cell lines (wild-type for both genes). A significant correlation exists between MRE11 expression levels and cytotoxicity to ABT-888 at 10 µM. Flow cytometry analyses show ...
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77. PARP inhibitor and Regorafenib
December 30, 2011
There have been several clinical studies conducted on the efficiency of PARP inhibitors on the actions of preventing the spread of cancer within the body. Studies have concluded that three times as many women that used this drug had positive results of this new anti-cancer therapy. This syntheticall...
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78. Exploration of targets for Crohn's disease
December 30, 2011
parp inhibitors, PLX-4032 more. angiogenesis inhibitors apoptosis inhibitors Compound Libraries References [1]. Inflamm Bowel Dis 2011;000:000–000.
Related Post The roles of IL-27 in the treatment of patients with IBD">...
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79. M-110, the novel Pim inhibitor
December 22, 2011
In the last post, I have introduced the Pim kinases, the kinase inhibitor SGI-1776 and their action in the process and treatment of AML. And I will continue to talk about the Pim inhibitors and the corresponding mechanism in the regulation of JAK/STAT signaling pathway. As I have mentioned in my pre...
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80. Mechanism of Resistance to IGF1R Inhibitor NVP-AEW541 in Rhabdomyosarcoma
December 22, 2011
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer and the most common soft tissue sarcoma of childhood. Insulin-like growth factor (IGF) signaling has a long precedent of relevance in ARMS. Despite the potential impact of Igf1r inhibition, we expect resistance to evolve in a subset of patients. ...
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Author: kate edson
